1
|
Derynck R and Zhang YE: Smad-dependent and
Smad-independent pathways in TGF-beta family signalling. Nature.
425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI
|
2
|
Neuzillet C, Tijeras-Raballand A, Cohenb
R, Cros J, Faivre S, Raymond E and de Gramont A: Targeting the TGFβ
pathway for cancer therapy. Pharmacol Ther. 147:22–31. 2015.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Inman GJ: Switching TGFβ from a tumour
suppressor to a tumour promoter. Curr Opin Genet Dev. 21:93–99.
2011. View Article : Google Scholar : PubMed/NCBI
|
4
|
Principe DR, Doll JA, Bauer J, Jung B,
Munshi HG, Bartholin L, Pasche B, Lee C and Grippo PJ: TGF-β:
Duality of function between tumour prevention and carcinogenesis. J
Natl Cancer Inst. 106:djt3692014. View Article : Google Scholar : PubMed/NCBI
|
5
|
Jakowlew SB: Transforming growth
factor-beta in cancer and metastasis. Cancer Metastasis Rev.
25:435–457. 2006. View Article : Google Scholar : PubMed/NCBI
|
6
|
Tian M, Neil JR and Schiemann WP:
Transforming growth factor-β and the hallmarks of cancer. Cell
Signal. 23:951–962. 2011. View Article : Google Scholar : PubMed/NCBI
|
7
|
Drabsch Y and ten Dijke P: TGF-β
signalling and its role in cancer progression and metastasis.
Cancer Metastasis Rev. 31:553–568. 2012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Wendt MK, Tian M and Schiemann WP:
Deconstructing the mechanisms and consequences of TGF-β-induced EMT
during cancer progression. Cell Tissue Res. 347:85–101. 2012.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Akhurst RJ and Hata A: Targeting the TGFβ
signalling pathway in disease. Nat Rev Drug Discov. 11:790–811.
2012. View
Article : Google Scholar : PubMed/NCBI
|
10
|
Yingling JM, Blanchard KL and Sawyer JS:
Development of TGF-beta signalling inhibitors for cancer therapy.
Nat Rev Drug Discov. 3:1011–1022. 2004. View Article : Google Scholar : PubMed/NCBI
|
11
|
Wiercinska E, Naber HP, Pardali E, van der
Pluijm G, van Dam H and ten Dijke P: The TGF-β/Smad pathway induces
breast cancer cell invasion through the up-regulation of matrix
metalloproteinase 2 and 9 in a spheroid invasion model system.
Breast Cancer Res Treat. 128:657–666. 2011. View Article : Google Scholar : PubMed/NCBI
|
12
|
Kingsley LA, Fournier PG, Chirgwin JM and
Guise TA: Molecular biology of bone metastasis. Mol Cancer Ther.
6:2609–2617. 2007. View Article : Google Scholar : PubMed/NCBI
|
13
|
Bennewith KL, Huang X, Ham CM, Graves EE,
Erler JT, Kambham N, Feazell J, Yang GP, Koong A and Giaccia AJ:
The role of tumor cell derived connective tissue growth factor
(CTGF/CCN2) in pancreatic tumor growth. Cancer Res. 69:775–784.
2009. View Article : Google Scholar : PubMed/NCBI
|
14
|
Gao Y, Shan N, Zhao C, Wang Y, Xu F, Li J,
Yu X, Gao L and Yi Z: LY2109761 enhances cisplatin antitumor
activity in ovarian cancer cells. Int J Clin Exp Pathol.
8:4923–4932. 2015.PubMed/NCBI
|
15
|
Gaspar NJ, Li L, Kapoun AM, Medicherla S,
Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, et al:
Inhibition of transforming growth factor beta signaling reduces
pancreatic adenocarcinoma growth and invasiveness. Mol Pharmacol.
72:152–161. 2007. View Article : Google Scholar : PubMed/NCBI
|
16
|
Melisi D, Ishiyama S, Sclabas GM, Fleming
JB, Xia Q, Tortora G, Abbruzzese JL and Chiao PJ: LY2109761, a
novel transforming growth factor beta receptor type I and type II
dual inhibitor, as a therapeutic approach to suppressing pancreatic
cancer metastasis. Mol Cancer Ther. 7:829–840. 2008. View Article : Google Scholar : PubMed/NCBI
|
17
|
Schlingensiepen KH, Jaschinski F, Lang SA,
Moser C, Geissler EK, Schlitt HJ, Kielmanowicz M and Schneider A:
Transforming growth factor-beta 2 gene silencing with trabedersen
(AP 12009) in pancreatic cancer. Cancer Sci. 102:1193–1200. 2011.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Xu Y, Tabe Y, Jin L, Watt J, McQueen T,
Ohsaka A, Andreeff M and Konopleva M: TGF-beta receptor kinase
inhibitor LY2109761 reverses the anti-apoptotic effects of
TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with
stromal cells. Br J Haematol. 142:192–201. 2008. View Article : Google Scholar : PubMed/NCBI
|