Open Access

Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer

  • Authors:
    • Takao Iemoto
    • Shin Nishiumi
    • Takashi Kobayashi
    • Seiji Fujigaki
    • Tetsuya Hamaguchi
    • Ken Kato
    • Hirokazu Shoji
    • Yasuhiro Matsumura
    • Kazufumi Honda
    • Masaru Yoshida
  • View Affiliations

  • Published online on: November 19, 2018     https://doi.org/10.3892/ol.2018.9731
  • Pages: 831-842
  • Copyright: © Iemoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The survival times of patients with advanced colorectal cancer (CRC) have increased due to the introduction of chemotherapy involving irinotecan and cetuximab. However, further studies are required on the effective pretreatment methods for identifying patients with CRC who would respond to particular treatments. The aim of the present study was to identify biomarkers for predicting the efficacy of chemotherapy for CRC. A total of 123 serum samples were collected from 31 patients with CRC just prior to each of the first four rounds of chemotherapy. Serum metabolome analysis was performed using a multiplatform metabolomics system, and univariate Cox regression hazards analysis of the time to disease progression was conducted. Octanoic acid and 1,5‑anhydro‑D‑glucitol were identified as biomarker candidates. In addition, the serum level of octanoic acid was indicated to be significantly associated with the time to disease progression (hazard ratio, 3.3; 95% confidence interval, 1.099‑11.840; P=0.033). The serum levels of fatty acids, in particular polyunsaturated fatty acids, tended to be downregulated in the partial response group. The findings of the present study suggest that the serum level of octanoic acid may serve as a useful predictor for the prognosis of CRC.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Iemoto T, Nishiumi S, Kobayashi T, Fujigaki S, Hamaguchi T, Kato K, Shoji H, Matsumura Y, Honda K, Yoshida M, Yoshida M, et al: Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer. Oncol Lett 17: 831-842, 2019
APA
Iemoto, T., Nishiumi, S., Kobayashi, T., Fujigaki, S., Hamaguchi, T., Kato, K. ... Yoshida, M. (2019). Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer. Oncology Letters, 17, 831-842. https://doi.org/10.3892/ol.2018.9731
MLA
Iemoto, T., Nishiumi, S., Kobayashi, T., Fujigaki, S., Hamaguchi, T., Kato, K., Shoji, H., Matsumura, Y., Honda, K., Yoshida, M."Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer". Oncology Letters 17.1 (2019): 831-842.
Chicago
Iemoto, T., Nishiumi, S., Kobayashi, T., Fujigaki, S., Hamaguchi, T., Kato, K., Shoji, H., Matsumura, Y., Honda, K., Yoshida, M."Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer". Oncology Letters 17, no. 1 (2019): 831-842. https://doi.org/10.3892/ol.2018.9731