Open Access

Significance of TERT and ATRX mutations in glioma

  • Authors:
    • Jiayu Liu
    • Xuebin Zhang
    • Xiaoling Yan
    • Mei Sun
    • Yueshan Fan
    • Ying Huang
  • View Affiliations

  • Published online on: October 29, 2018     https://doi.org/10.3892/ol.2018.9634
  • Pages: 95-102
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mutations of telomerase reverse transcriptase (TERT) and the α thalassemia/mental retardation syndrome X‑linked (ATRX) genes have been the subject of numerous studies on the classification and prognosis of glioma. However, the association between TERT and ATRX in World Health Organization (WHO) grade II to IV glioma remains unclear. The present study utilized Sanger sequencing and immunohistochemical methods to detect the expression of the TERT promoter region, ATRX mutations and proliferation marker protein Ki‑67 (Ki‑67) protein expression in 179 cases of glioma. The current study analyzed these variables and their association with clinicopathological characteristics to further basic research and provide a theoretical basis for the clinical diagnosis and treatment of this type of tumor (1). The results demonstrated that TERT promoter mutations were negatively associated with ATRX. Additionally, Ki‑67 protein expression in TERT wild‑type samples was higher compared with samples with ATRX deletion. Overall, the results demonstrated, for the first time to the best of the authors' knowledge, that TERT promoter mutations are negatively associated with ATRX expression in WHO grade II to IV gliomas. These findings provide a theoretical basis for further basic research and may improve clinical diagnosis and treatment of glioma in the future.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu J, Zhang X, Yan X, Sun M, Fan Y and Huang Y: Significance of TERT and ATRX mutations in glioma. Oncol Lett 17: 95-102, 2019
APA
Liu, J., Zhang, X., Yan, X., Sun, M., Fan, Y., & Huang, Y. (2019). Significance of TERT and ATRX mutations in glioma. Oncology Letters, 17, 95-102. https://doi.org/10.3892/ol.2018.9634
MLA
Liu, J., Zhang, X., Yan, X., Sun, M., Fan, Y., Huang, Y."Significance of TERT and ATRX mutations in glioma". Oncology Letters 17.1 (2019): 95-102.
Chicago
Liu, J., Zhang, X., Yan, X., Sun, M., Fan, Y., Huang, Y."Significance of TERT and ATRX mutations in glioma". Oncology Letters 17, no. 1 (2019): 95-102. https://doi.org/10.3892/ol.2018.9634