Open Access

Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells

  • Authors:
    • Wen‑Xue Chen
    • Jin‑Gao Li
    • Xiang‑Hui Wan
    • Xue‑Sen Zou
    • Shu‑Yi Qi
    • Yu‑Qing Zhang
    • Qiu‑Min Weng
    • Jun‑Yu Li
    • Wen‑Min Xiong
    • Chen Xie
    • Wei‑Liang Cheng
  • View Affiliations

  • Published online on: November 28, 2018     https://doi.org/10.3892/ol.2018.9771
  • Pages: 1581-1588
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to discuss the design of a microfluidic chip consisting of columns, and its use for the enrichment of nasopharyngeal cancer (NPC) cells. A microfluidic chip experiment was simulated using FLUENT software. Within the microfluidic chip, aptamers were bound to the reaction chamber (consisting of columns) using a biotin‑avidin system. Cell suspension was introduced into the reaction chamber to capture NPC cells. NPC cells were subsequently eluted, and the capture rate of the cells was calculated. The modified aptamer‑bound microfluidic chip was able to capture NPC cells with a capture rate of ~90%. The modified aptamer‑bound microfluidic chip has a wide range of potential applications for the diagnosis of NPC.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen WX, Li JG, Wan XH, Zou XS, Qi SY, Zhang YQ, Weng QM, Li JY, Xiong WM, Xie C, Xie C, et al: Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells. Oncol Lett 17: 1581-1588, 2019
APA
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y. ... Cheng, W. (2019). Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells. Oncology Letters, 17, 1581-1588. https://doi.org/10.3892/ol.2018.9771
MLA
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y., Weng, Q., Li, J., Xiong, W., Xie, C., Cheng, W."Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells". Oncology Letters 17.2 (2019): 1581-1588.
Chicago
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y., Weng, Q., Li, J., Xiong, W., Xie, C., Cheng, W."Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells". Oncology Letters 17, no. 2 (2019): 1581-1588. https://doi.org/10.3892/ol.2018.9771