Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin B1 and MMP‑9 and upregulation of p38‑MAPK signaling

  • Authors:
    • Zhiyu Yan
    • Guang Liu
    • Min Liang
    • Yanjun Xu
  • View Affiliations

  • Published online on: December 3, 2018     https://doi.org/10.3892/ol.2018.9788
  • Pages: 1877-1882
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Abstract

The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti‑aging effects, improvement in learning deficit and dysmnesia, anti‑tumor, anti‑radiation and anti‑inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesions. However, the efficacy of Ophiopogonin D on human laryngocarcinoma remains to be elucidated. The present study therefore investigated whether the anti‑cancer effect of Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma. In the present study, it was found that Ophiopogonin D inhibited cell proliferation, promoted cytotoxicity, induced apoptosis and increased caspase‑3/9 activity in human laryngocarcinoma cells. Ophiopogonin D significantly suppressed cyclin B1 and matrix metalloproteinase‑9 (MMP‑9) protein expression, and upregulated p‑p38 MAPK protein expression in human laryngocarcinoma cells. Together, these results suggest Ophiopogonin D inhibits cell proliferation and induced apoptosis in human laryngocarcinoma cells through downregulation of cyclin B1 and MMP‑9 and upregulation of the p38 MAPK signaling pathway. Therefore, Ophiopogonin D may be a potential therapy for the treatment of human laryngocarcinoma.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yan Z, Liu G, Liang M and Xu Y: Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin B1 and MMP‑9 and upregulation of p38‑MAPK signaling. Oncol Lett 17: 1877-1882, 2019
APA
Yan, Z., Liu, G., Liang, M., & Xu, Y. (2019). Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin B1 and MMP‑9 and upregulation of p38‑MAPK signaling. Oncology Letters, 17, 1877-1882. https://doi.org/10.3892/ol.2018.9788
MLA
Yan, Z., Liu, G., Liang, M., Xu, Y."Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin B1 and MMP‑9 and upregulation of p38‑MAPK signaling". Oncology Letters 17.2 (2019): 1877-1882.
Chicago
Yan, Z., Liu, G., Liang, M., Xu, Y."Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin B1 and MMP‑9 and upregulation of p38‑MAPK signaling". Oncology Letters 17, no. 2 (2019): 1877-1882. https://doi.org/10.3892/ol.2018.9788