MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway

  • Authors:
    • Dianhui Xiu
    • Dawei Wang
    • Jing Wang
    • Fujian Ji
    • Wenlei Zhang
  • View Affiliations

  • Published online on: December 17, 2018     https://doi.org/10.3892/ol.2018.9838
  • Pages: 2451-2456
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Abstract

The aim of the present study was to investigate the function of microRNA‑543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA‑543. When compared with paracarcinoma tissue, microRNA‑543 expression in tissue samples from patients with liver cancer was identified to be decreased. Furthermore, overall survival of patients with high microRNA‑543 expression was increased compared with patients with low microRNA‑543 expression. Inhibition of microRNA‑543 expression increased cell proliferation and decreased apoptosis of liver cancer cells. It also activated the protein expression of phosphorylated JAK2, phosphorylated STAT3, c‑Myc and B‑cell lymphoma 2 (Bcl‑2) in liver cancer cells. However, activation of microRNA‑543 expression in turn decreased cell proliferation and increased apoptosis of liver cancer cells. The results of the present study highlight the pivotal function of microRNA‑543 as an inhibitor in liver cancer cell proliferation by observing JAK2/STAT3/c‑Myc/Bcl‑2 in liver cancer.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xiu D, Wang D, Wang J, Ji F and Zhang W: MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway. Oncol Lett 17: 2451-2456, 2019
APA
Xiu, D., Wang, D., Wang, J., Ji, F., & Zhang, W. (2019). MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway. Oncology Letters, 17, 2451-2456. https://doi.org/10.3892/ol.2018.9838
MLA
Xiu, D., Wang, D., Wang, J., Ji, F., Zhang, W."MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway". Oncology Letters 17.2 (2019): 2451-2456.
Chicago
Xiu, D., Wang, D., Wang, J., Ji, F., Zhang, W."MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway". Oncology Letters 17, no. 2 (2019): 2451-2456. https://doi.org/10.3892/ol.2018.9838