Open Access

Hepatic blood flow by perfusion computed tomography as an imaging biomarker for patients with gastric cancer

  • Authors:
    • Kiyohiko Shuto
    • Mikito Mori
    • Chihiro Kosugi
    • Kazuo Narushima
    • Satoko Nakabayashi
    • Takeshi Fujisiro
    • Asami Sato
    • Koichi Hayano
    • Hiroaki Shimizu
    • Keiji Koda
  • View Affiliations

  • Published online on: January 25, 2019     https://doi.org/10.3892/ol.2019.9969
  • Pages: 3267-3276
  • Copyright: © Shuto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Perfusion computed tomography (PCT) is a less invasive imaging modality that provides information about tissue hemodynamics at the capillary level. The present study aimed to investigate the correlation between hepatic perfusion and gastric cancer progression. A total of 136 patients with gastric adenocarcinoma were evaluated in the present study. Prior to initial treatment, liver PCT was performed across the hepatic hilar plane and the hepatic blood flow (HBF) was measured using the dual‑input deconvolution method. HBF was compared with clinicopathological factors, patient prognosis and circulating serum proangiogenic cytokines. The median HBF was 217 ml/min/100 g tissue. Patients with high HBF had larger tumors (43 mm vs. 71, P<0.001) and more advanced tumor‑node stages (P<0.001 for both). When both patient groups of operable and inoperable were compared by their respective median HBF values, each high‑HBF group had a significantly worse prognosis (P=0.002 and P=0.024), notably in the inoperable group, with <1‑year survival. In 17 postoperative recurrent patients, the high‑HBF at recurrence group also had a significantly worse postrecurrent prognosis (P=0.019). HBF was an independent prognostic factor (hazard ratio, 2.019; P=0.048) and was strongly associated with serum vascular endothelial growth factor level (R=0.607, P<0.001). HBF was significantly correlated with gastric cancer progression, and is an easily measured imaging biomarker reflecting patient survival.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shuto K, Mori M, Kosugi C, Narushima K, Nakabayashi S, Fujisiro T, Sato A, Hayano K, Shimizu H, Koda K, Koda K, et al: Hepatic blood flow by perfusion computed tomography as an imaging biomarker for patients with gastric cancer. Oncol Lett 17: 3267-3276, 2019
APA
Shuto, K., Mori, M., Kosugi, C., Narushima, K., Nakabayashi, S., Fujisiro, T. ... Koda, K. (2019). Hepatic blood flow by perfusion computed tomography as an imaging biomarker for patients with gastric cancer. Oncology Letters, 17, 3267-3276. https://doi.org/10.3892/ol.2019.9969
MLA
Shuto, K., Mori, M., Kosugi, C., Narushima, K., Nakabayashi, S., Fujisiro, T., Sato, A., Hayano, K., Shimizu, H., Koda, K."Hepatic blood flow by perfusion computed tomography as an imaging biomarker for patients with gastric cancer". Oncology Letters 17.3 (2019): 3267-3276.
Chicago
Shuto, K., Mori, M., Kosugi, C., Narushima, K., Nakabayashi, S., Fujisiro, T., Sato, A., Hayano, K., Shimizu, H., Koda, K."Hepatic blood flow by perfusion computed tomography as an imaging biomarker for patients with gastric cancer". Oncology Letters 17, no. 3 (2019): 3267-3276. https://doi.org/10.3892/ol.2019.9969