Open Access

Inflammation: A key process in skin tumorigenesis (Review)

  • Authors:
    • Monica Neagu
    • Carolina Constantin
    • Constantin Caruntu
    • Carmen Dumitru
    • Mihaela Surcel
    • Sabina Zurac
  • View Affiliations

  • Published online on: November 19, 2018     https://doi.org/10.3892/ol.2018.9735
  • Pages: 4068-4084
  • Copyright: © Neagu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microenvironment that can lead to pro‑tumorigenic processes. Regardless of the origin of the environmental factors, the maintenance of an inflammatory microenvironment is a clear condition that favors tumorigenesis. Inflammation sustains the proliferation and survival of malignant transformed cells, can promote angiogenesis and metastatic processes, can negatively regulate the antitumoral adaptive and innate immune responses and may alter the efficacy of therapeutic agents. There is an abundance of studies focusing on molecular pathways that trigger inflammation-mediated tumorigenesis, and these data have revealed a series of biomarkers that can improve the diagnosis and prognosis in oncology. In skin there is a clear connection between tissue destruction, inflammation and tumor onset. Inflammation is a self‑limiting process in normal physiological conditions, while tumor is a constitutive process activating new pro‑tumor mechanisms. Among skin cancers, the most commonly diagnosed skin cancers, squamous cell carcinoma and basal cell carcinoma (BCC) have important inflammatory components. The most aggressive skin cancer, melanoma, is extensively research in regards to the new context of novel developed immune‑therapies. In skin cancers, inflammatory markers can find their place in the biomarker set for improvement of diagnosis and prognosis.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Neagu M, Constantin C, Caruntu C, Dumitru C, Surcel M and Zurac S: Inflammation: A key process in skin tumorigenesis (Review). Oncol Lett 17: 4068-4084, 2019
APA
Neagu, M., Constantin, C., Caruntu, C., Dumitru, C., Surcel, M., & Zurac, S. (2019). Inflammation: A key process in skin tumorigenesis (Review). Oncology Letters, 17, 4068-4084. https://doi.org/10.3892/ol.2018.9735
MLA
Neagu, M., Constantin, C., Caruntu, C., Dumitru, C., Surcel, M., Zurac, S."Inflammation: A key process in skin tumorigenesis (Review)". Oncology Letters 17.5 (2019): 4068-4084.
Chicago
Neagu, M., Constantin, C., Caruntu, C., Dumitru, C., Surcel, M., Zurac, S."Inflammation: A key process in skin tumorigenesis (Review)". Oncology Letters 17, no. 5 (2019): 4068-4084. https://doi.org/10.3892/ol.2018.9735