Open Access

AMP‑activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non‑small cell lung cancer

  • Authors:
    • Gong Dao Hui
    • Wang Yu Xiu
    • Chen Yong
    • Chi Bei Yuan
    • Zhang Jun
    • Gu Jian Jun
    • Yang Jun Jun
    • Xu Xing Xiang
    • Hu Su Wei
    • Min Ling Feng
  • View Affiliations

  • Published online on: March 8, 2019     https://doi.org/10.3892/ol.2019.10126
  • Pages: 4329-4334
  • Copyright: © Hui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

AMP‑activated protein kinase α1 (AMPK α1) is involved in the tumorigenesis of various cancer types. However, the role of AMPK α1 in non‑small cell lung cancer (NSCLC) remains unclear. In the present study, 99 NSCLC tumor tissues and paired normal tissues were obtained. The expression levels of AMPK α1 were significantly upregulated in NSCLC tumor tissues compared with those in adjacent non‑tumor lung tissues. The patients were further divided into two groups according to their expression levels of AMPK α1 in tumor tissues. The results outlined that overexpression of AMPK α1 was associated with poor prognosis. In addition, vascular endothelial growth factor (VEGF) expression levels were associated with malignant progression in patients with NSCLC. Patients with NSCLC that overexpressed AMPK α1 and VEGF had the worst outcomes. Moreover, AMPK α1 may positively regulate VEGF expression. These results suggest that AMPK α1 serves a carcinogenic role at least in part through the regulation of VEGF expression, and thus represents a potential treatment target in patients with NSCLC.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Hui GD, Xiu WY, Yong C, Yuan CB, Jun Z, Jun GJ, Jun YJ, Xiang XX, Wei HS, Feng ML, Feng ML, et al: AMP‑activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non‑small cell lung cancer. Oncol Lett 17: 4329-4334, 2019
APA
Hui, G.D., Xiu, W.Y., Yong, C., Yuan, C.B., Jun, Z., Jun, G.J. ... Feng, M.L. (2019). AMP‑activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non‑small cell lung cancer. Oncology Letters, 17, 4329-4334. https://doi.org/10.3892/ol.2019.10126
MLA
Hui, G. D., Xiu, W. Y., Yong, C., Yuan, C. B., Jun, Z., Jun, G. J., Jun, Y. J., Xiang, X. X., Wei, H. S., Feng, M. L."AMP‑activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non‑small cell lung cancer". Oncology Letters 17.5 (2019): 4329-4334.
Chicago
Hui, G. D., Xiu, W. Y., Yong, C., Yuan, C. B., Jun, Z., Jun, G. J., Jun, Y. J., Xiang, X. X., Wei, H. S., Feng, M. L."AMP‑activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non‑small cell lung cancer". Oncology Letters 17, no. 5 (2019): 4329-4334. https://doi.org/10.3892/ol.2019.10126