Differential expression of EphA5 protein in gastric carcinoma and its clinical significance

  • Authors:
    • Wei Zhang
    • Xue Wei
    • Shuwei Guo
    • Jiandong Wang
    • Jing Liu
    • Hai Wang
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/ol.2019.10167
  • Pages: 5147-5153
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Abstract

The aim of the present study was to evaluate ephrin type‑A receptor 5 (EphA5) expression and its clinicopathological significance in gastric cancer. Gastric cancer tissues were analyzed by immunohistochemistry. The association between EphA5 expression and clinicopathological parameters, human epidermal growth factor receptor 2 (HER2) status and Ki‑67 proliferation index was statistically analyzed. EphA5 expression was detected in all non‑tumor gastric epithelia but was differentially expressed among gastric cancer samples. EphA5 was negatively expressed in 30/110 (27.3%) and positively expressed in 80/110 (72.3%) samples from patients with gastric cancer. EphA5 expression was significantly associated with Lauren classification (P=0.032), lymph node metastasis (P<0.001), HER2 expression (P=0.020) and Ki‑67 expression (P=0.005). No significant association was determined between EphA5 expression and age, sex, primary location, depth of invasion and Tumor‑Node‑Metastasis stage. The present data indicated that EphA5 is differentially expressed in gastric cancer. EphA5 may therefore be a potential therapeutic target and may have clinical utility as a marker for lymph node metastasis in gastric cancer.
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June-2019
Volume 17 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang W, Wei X, Guo S, Wang J, Liu J and Wang H: Differential expression of EphA5 protein in gastric carcinoma and its clinical significance. Oncol Lett 17: 5147-5153, 2019
APA
Zhang, W., Wei, X., Guo, S., Wang, J., Liu, J., & Wang, H. (2019). Differential expression of EphA5 protein in gastric carcinoma and its clinical significance. Oncology Letters, 17, 5147-5153. https://doi.org/10.3892/ol.2019.10167
MLA
Zhang, W., Wei, X., Guo, S., Wang, J., Liu, J., Wang, H."Differential expression of EphA5 protein in gastric carcinoma and its clinical significance". Oncology Letters 17.6 (2019): 5147-5153.
Chicago
Zhang, W., Wei, X., Guo, S., Wang, J., Liu, J., Wang, H."Differential expression of EphA5 protein in gastric carcinoma and its clinical significance". Oncology Letters 17, no. 6 (2019): 5147-5153. https://doi.org/10.3892/ol.2019.10167