Open Access

Prioritization and comprehensive analysis of genes associated with melanoma

  • Authors:
    • Cheng Feng
    • Ming Bai
    • Hailin Zhang
    • Ang Zeng
    • Wenchao Zhang
  • View Affiliations

  • Published online on: April 25, 2019     https://doi.org/10.3892/ol.2019.10284
  • Pages: 127-136
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is a malignant tumor derived from melanocytes, which occurs mostly in the skin. A major challenge in cancer research is the biological interpretation of the complexity of cancer somatic mutation profiles. The aim of the present study was to obtain a comprehensive understanding of the formation and development of melanoma and to identify its associated genes. In the present study, a pipeline was proposed for investigating key genes associated with melanoma based on the Online Mendelian Inheritance in Man and Search Tool for the Retrieval of Interacting Genes/Proteins databases through a random walk model. Additionally, functional enrichment analysis was performed for key genes associated with melanoma. This identified a total of 17 biological processes and 30 pathways which may be associated with melanoma. In addition, melanoma‑specific network analysis followed by Kaplan‑Meier analysis along with log‑rank tests identified tyrosinase, hedgehog acyltransferase, BRCA1‑associated protein 1 and melanocyte inducing transcription factor as potential therapeutic targets for melanoma. In conclusion, the present study increased the knowledge of melanoma progression and may be helpful for improving its prognosis.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Feng C, Bai M, Zhang H, Zeng A and Zhang W: Prioritization and comprehensive analysis of genes associated with melanoma. Oncol Lett 18: 127-136, 2019
APA
Feng, C., Bai, M., Zhang, H., Zeng, A., & Zhang, W. (2019). Prioritization and comprehensive analysis of genes associated with melanoma. Oncology Letters, 18, 127-136. https://doi.org/10.3892/ol.2019.10284
MLA
Feng, C., Bai, M., Zhang, H., Zeng, A., Zhang, W."Prioritization and comprehensive analysis of genes associated with melanoma". Oncology Letters 18.1 (2019): 127-136.
Chicago
Feng, C., Bai, M., Zhang, H., Zeng, A., Zhang, W."Prioritization and comprehensive analysis of genes associated with melanoma". Oncology Letters 18, no. 1 (2019): 127-136. https://doi.org/10.3892/ol.2019.10284