Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury

  • Authors:
    • Gaohua Han
    • Kaijin Lu
    • Wansong Xu
    • Sihui Zhang
    • Junxing Huang
    • Chunlei Dai
    • Guangzhi Sun
    • Jun Ye
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  • Published online on: May 6, 2019     https://doi.org/10.3892/ol.2019.10317
  • Pages: 321-329
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Abstract

The present study evaluated the role of annexin A1 (ANXA1) in the treatment of acute radiation‑induced lung injury (RILI) and investigated the mechanism of its action. The expression of ANXA1, interleukin‑6 (IL‑6) and myeloperoxidase (MPO) in the plasma of patients with RILI prior to and following hormonotherapy was assessed by enzyme‑linked immunosorbent assay. The association of plasma ANXA1 concentration with clinical effect, and the correlation between the expression of ANXA1 and that of IL‑6 and MPO were evaluated. ANXA1 was overexpressed or knocked down in a macrophage cell line, and its impact on IL‑6 and MPO expression was measured. Following glucocorticoid hormonotherapy, patients with RILI exhibited a higher plasma concentration of ANXA1 compared with that prior to treatment, while IL‑6 and MPO levels were lower. The concentration of ANXA1 in plasma was negatively correlated with IL‑6 and MPO levels, with a correlation coefficient of ‑0.492 and ‑0.437, respectively (P<0.001). The increasing concentration of ANXA1 in plasma following treatment was associated with the clinical effect in patients with RILI (P=0.007). The expression levels of of IL‑6 and MPO were inhibited both in the cytoplasm and in the culture solution, when ANXA1 expression was upregulated in a macrophage cell line. In conclusion, ANXA1 inhibited the synthesis and secretion of IL‑6 and MPO inflammatory cytokines, indicating that ANXA1 may have therapeutic potential as a treatment target for RILI.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Han G, Lu K, Xu W, Zhang S, Huang J, Dai C, Sun G and Ye J: Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury. Oncol Lett 18: 321-329, 2019
APA
Han, G., Lu, K., Xu, W., Zhang, S., Huang, J., Dai, C. ... Ye, J. (2019). Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury. Oncology Letters, 18, 321-329. https://doi.org/10.3892/ol.2019.10317
MLA
Han, G., Lu, K., Xu, W., Zhang, S., Huang, J., Dai, C., Sun, G., Ye, J."Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury". Oncology Letters 18.1 (2019): 321-329.
Chicago
Han, G., Lu, K., Xu, W., Zhang, S., Huang, J., Dai, C., Sun, G., Ye, J."Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury". Oncology Letters 18, no. 1 (2019): 321-329. https://doi.org/10.3892/ol.2019.10317