Open Access

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

  • Authors:
    • Kanwal Ahmed
    • Syed Faisal Zaidi
    • Zheng‑Guo Cui
    • Dejun Zhou
    • Sheikh Abdul Saeed
    • Hidekuni Inadera
  • View Affiliations

  • Published online on: May 13, 2019     https://doi.org/10.3892/ol.2019.10349
  • Pages: 487-498
  • Copyright: © Ahmed et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo‑resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fruits and vegetables have a significantly reduced incidence rate of CRC. This chemo‑preventive effect is primarily associated with the presence of phytochemicals in the dietary components. Plant‑derived chemical agents act as a prominent source of novel compounds for drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. Despite promising results from experimental studies, only a limited number of phytochemicals have entered into clinical trials. The purpose of the current review is to compile previously published pre‑clinical and clinical evidence of phytochemicals in cases of CRC. A PubMed, Google Scholar and Science Direct search was performed for relevant articles published between 2008‑2018 using the following key terms: ‘Phytochemicals with colorectal cancers’, ‘apoptosis’, ‘cell cycle’, ‘reactive oxygen species’ and ‘clinical anticancer activities’. The present review may aid in identifying the most investigated phytochemicals in CRC cells, and due to the limited number of studies that make it from the laboratory bench to clinical trial stage, may provide a novel foundation for future research.
View Figures
View References

Related Articles

Journal Cover

July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ahmed K, Zaidi SF, Cui ZG, Zhou D, Saeed SA and Inadera H: Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review). Oncol Lett 18: 487-498, 2019
APA
Ahmed, K., Zaidi, S.F., Cui, Z., Zhou, D., Saeed, S.A., & Inadera, H. (2019). Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review). Oncology Letters, 18, 487-498. https://doi.org/10.3892/ol.2019.10349
MLA
Ahmed, K., Zaidi, S. F., Cui, Z., Zhou, D., Saeed, S. A., Inadera, H."Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)". Oncology Letters 18.1 (2019): 487-498.
Chicago
Ahmed, K., Zaidi, S. F., Cui, Z., Zhou, D., Saeed, S. A., Inadera, H."Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)". Oncology Letters 18, no. 1 (2019): 487-498. https://doi.org/10.3892/ol.2019.10349