Open Access

Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase‑3

  • Authors:
    • Chunlei Liu
    • Mingzhu Ge
    • Jun Ma
    • Yanhui Zhang
    • Yanhui Zhao
    • Tao Cui
  • View Affiliations

  • Published online on: May 3, 2019     https://doi.org/10.3892/ol.2019.10312
  • Pages: 49-56
  • Copyright : © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Homeobox A10 (HOXA10) belongs to the family of HOX genes, which are closely connected with embryonic development and serve important roles in various tumors. However, the role of HOXA10 in bladder cancer (BC) remains unclear. In the present study, the role of HOXA10 in BC and the underlying mechanisms by which it promotes the disease progression were investigated. Immunohistochemical analysis demonstrated that the expression of the HOXA10 protein was significantly higher in BC tissues as compared with that in adjacent normal tissues. Subsequent statistical analysis revealed that upregulation of HOXA10 was significantly associated with the pathological grade and clinical stage of BC patients. In the BC cell lines T24 and 5637, silencing of HOXA10 by small interfering RNA transfection suppressed the proliferation, migration and invasion of BC cells, and led to decreased matrix metalloproteinase‑3 expression. Taken together, overexpression of HOXA10 may be associated with poor prognosis in BC, and may serve as a novel antitumor therapy target for the treatment of this disease.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu C, Ge M, Ma J, Zhang Y, Zhao Y and Cui T: Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase‑3. Oncol Lett 18: 49-56, 2019
APA
Liu, C., Ge, M., Ma, J., Zhang, Y., Zhao, Y., & Cui, T. (2019). Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase‑3. Oncology Letters, 18, 49-56. https://doi.org/10.3892/ol.2019.10312
MLA
Liu, C., Ge, M., Ma, J., Zhang, Y., Zhao, Y., Cui, T."Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase‑3". Oncology Letters 18.1 (2019): 49-56.
Chicago
Liu, C., Ge, M., Ma, J., Zhang, Y., Zhao, Y., Cui, T."Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase‑3". Oncology Letters 18, no. 1 (2019): 49-56. https://doi.org/10.3892/ol.2019.10312