Open Access

Cyclin A1 is associated with poor prognosis in oesophageal squamous cell carcinoma

  • Authors:
    • Xiaoting He
    • Suqing Li
    • Weihong Shi
    • Qingfeng Lin
    • Jian Ma
    • Yang Liu
    • Tingting Feng
    • Xiufeng Cao
  • View Affiliations

  • Published online on: May 20, 2019     https://doi.org/10.3892/ol.2019.10377
  • Pages: 706-712
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dysregulation of cyclin A1 (CCNA1) is implicated in the carcinogenesis, progression and metastasis of many types of solid tumours. In the present study, an mRNA single‑channel expression profile chip experiment revealed that the CCNA1 mRNA levels in oesophageal squamous cell carcinoma (ESCC) were increased >10‑fold compared with those in the adjacent non‑cancer tissues. Reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry analyses were performed to additionally investigate the role of CCNA1 in the development and progression of ESCC in patients treated by radical resection of the oesophagus. The association between CCNA1 mRNA expression and the clinicopathological parameters of patients with ESCC was statistically analysed. The results indicated that upregulation of CCNA1 occurred in ~70% of patients with ESCC, and increased CCNA1 mRNA expression was significantly associated with advanced clinical stage, lymph node metastasis, invasiveness and poor clinical outcome, including disease‑free survival and overall survival rates. Taken together, the data suggested that CCNA1 had an important function in ESCC development and progression, and may serve as a prognostic biomarker and therapeutic target in ESCC.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
He X, Li S, Shi W, Lin Q, Ma J, Liu Y, Feng T and Cao X: Cyclin A1 is associated with poor prognosis in oesophageal squamous cell carcinoma. Oncol Lett 18: 706-712, 2019
APA
He, X., Li, S., Shi, W., Lin, Q., Ma, J., Liu, Y. ... Cao, X. (2019). Cyclin A1 is associated with poor prognosis in oesophageal squamous cell carcinoma. Oncology Letters, 18, 706-712. https://doi.org/10.3892/ol.2019.10377
MLA
He, X., Li, S., Shi, W., Lin, Q., Ma, J., Liu, Y., Feng, T., Cao, X."Cyclin A1 is associated with poor prognosis in oesophageal squamous cell carcinoma". Oncology Letters 18.1 (2019): 706-712.
Chicago
He, X., Li, S., Shi, W., Lin, Q., Ma, J., Liu, Y., Feng, T., Cao, X."Cyclin A1 is associated with poor prognosis in oesophageal squamous cell carcinoma". Oncology Letters 18, no. 1 (2019): 706-712. https://doi.org/10.3892/ol.2019.10377