Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients

  • Authors:
    • Yibin Zhao
    • Ke Wu
    • Kailin Cai
    • Ronglin Zhai
    • Kaixiong Tao
    • Guobin Wang
    • Jiliang Wang
  • View Affiliations

  • Published online on: July 27, 2012     https://doi.org/10.3892/ol.2012.830
  • Pages: 755-758
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Abstract

Mast cells (MCs) and regulatory T cells (Tregs) are the important components of the inflammatory infiltrating leukocytes in most malignant tumors. Our study was designed to investigate the infiltrating correlation between MCs and Tregs and clarify their prognostic significance in gastric cancer (GC). A total of 60 fresh GC tissues were collected and tumor-infiltrating leukocytes were isolated by gradient centrifugation. Tryptase and Foxp3 were used as markers for MCs and Tregs, respectively. The expression of tryptase and Foxp3 was determined in tumor-infiltrating leukocytes using flow cytometry. The expression of tryptase and Foxp3 were positively correlated. The increased infiltration of MCs correlated significantly with advanced stage of GC. The infiltration of MCs into the tumor may increase the number of Tregs. Tryptase is a promising marker to stratify GC patients into different risk groups.
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October 2012
Volume 4 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao Y, Wu K, Cai K, Zhai R, Tao K, Wang G and Wang J: Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients. Oncol Lett 4: 755-758, 2012
APA
Zhao, Y., Wu, K., Cai, K., Zhai, R., Tao, K., Wang, G., & Wang, J. (2012). Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients. Oncology Letters, 4, 755-758. https://doi.org/10.3892/ol.2012.830
MLA
Zhao, Y., Wu, K., Cai, K., Zhai, R., Tao, K., Wang, G., Wang, J."Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients". Oncology Letters 4.4 (2012): 755-758.
Chicago
Zhao, Y., Wu, K., Cai, K., Zhai, R., Tao, K., Wang, G., Wang, J."Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients". Oncology Letters 4, no. 4 (2012): 755-758. https://doi.org/10.3892/ol.2012.830