Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

  • Authors:
    • Mitsuaki Ishida
    • Hisanori Shiomi
    • Shigeyuki Naka
    • Tohru Tani
    • Hidetoshi Okabe
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  • Published online on: October 3, 2012     https://doi.org/10.3892/ol.2012.952
  • Pages: 63-67
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Abstract

Intraductal papillary mucinous neoplasm (IPMN) and neuroendocrine tumor (NET) of the pancreas are rare tumors and their association is not expected to be frequent. However, certain studies have suggested that the concomitant occurence of these tumors may be more frequent than previously thought. In the current study, we describe a case of concomitant occurrence of IPMN and NET of the pancreas and review the clinicopathological features of previously published cases and the current one. A 68-year-old female was incidentally found to have dilatation of the main pancreatic duct. A distal pancreatectomy was performed under the clinical diagnosis of IPMN. Histopathological analysis revealed concomitant IPMN (low-grade) and NET G1 of the pancreas. Review of the clinicopathological features of the 15 previously reported cases of concomitant IPMN and NET of the pancreas as well as the present one indicated that: i) this condition mainly affects middle-aged females; ii) the main symptom is abdominal or back pain, or no symptoms; iii) a hormone production symptom was observed in only one case; iv) the most common degree of dysplasia of IPMN is low grade; and v) the size of the NET is not particularly large (average 15.1 mm), although the clinical behavior is not always indolent (metastasis was observed in 3 cases). It is well known that IPMNs are associated with a high incidence of extrapancreatic malignancies, including colorectal and gastric carcinomas. Concomitant pancreatic NET and extrapancreatic malignancies may occur, therefore, systemic surveillance of extrapancreatic neoplasms and detection of concomitant NETs of the pancreas are necessary for patients with IPMN.
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January 2013
Volume 5 Issue 1

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Spandidos Publications style
Ishida M, Shiomi H, Naka S, Tani T and Okabe H: Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas. Oncol Lett 5: 63-67, 2013
APA
Ishida, M., Shiomi, H., Naka, S., Tani, T., & Okabe, H. (2013). Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas. Oncology Letters, 5, 63-67. https://doi.org/10.3892/ol.2012.952
MLA
Ishida, M., Shiomi, H., Naka, S., Tani, T., Okabe, H."Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas". Oncology Letters 5.1 (2013): 63-67.
Chicago
Ishida, M., Shiomi, H., Naka, S., Tani, T., Okabe, H."Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas". Oncology Letters 5, no. 1 (2013): 63-67. https://doi.org/10.3892/ol.2012.952