Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report

  • Authors:
    • Ruo‑Zhi Xiao
    • Mu‑Jun Xiong
    • Zi‑Jie Long
    • Rui‑Fang Fan
    • Dong‑Jun Lin
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  • Published online on: December 27, 2013     https://doi.org/10.3892/ol.2013.1779
  • Pages: 713-716
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Abstract

Felty's syndrome (FS) is characterized by the three conditions of rheumatoid arthritis (RA), neutropenia and splenomegaly, and occurs in few cases of longstanding erosive RA. Discriminating between rare occurrences of autoimmune diseases and malignancies is crucial. The present study describes the case of a 17‑year‑old female with a two‑year history of RA, presenting with an irregular fever, hepatosplenomegaly and enlarged lymph nodes. The antinuclear antibody titer was 1:320, while antibody results for anti‑dsDNA, anti‑Sm and rheumatoid factor were negative. The clinical presentation was similar to that of lymphoma. However, the fluorodeoxyglucose‑positron emission tomography and biopsy examinations of the liver and cervical lymph node did not support the diagnosis of lymphoma. According to the laboratory results and clinical symptoms, the differential diagnosis indicated FS, and immunosuppressive agents were administered. Two weeks later, the patient no longer had a fever, and the transaminase levels were normal, associated with shrinkage of the liver and spleen.
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2014-March
Volume 7 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xiao RZ, Xiong MJ, Long ZJ, Fan RF and Lin DJ: Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report. Oncol Lett 7: 713-716, 2014
APA
Xiao, R., Xiong, M., Long, Z., Fan, R., & Lin, D. (2014). Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report. Oncology Letters, 7, 713-716. https://doi.org/10.3892/ol.2013.1779
MLA
Xiao, R., Xiong, M., Long, Z., Fan, R., Lin, D."Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report". Oncology Letters 7.3 (2014): 713-716.
Chicago
Xiao, R., Xiong, M., Long, Z., Fan, R., Lin, D."Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report". Oncology Letters 7, no. 3 (2014): 713-716. https://doi.org/10.3892/ol.2013.1779