The preventive effect of antineoplaston AS2-1 on HCC recurrence

  • Authors:
    • Hideaki Tsuda
    • Michio Sata
    • Tutomu Kumabe
    • Masafumi Uchida
    • Hiroshi Hara
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/or.10.2.391
  • Pages: 391-397
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Once hepatocellular carcinoma (HCC) develops, it repeats intrahepatic metastasis and has multicentric occurrence, which requires frequent treatment. We designed a phase II clinical trail to clarify whether antineoplaston AS2-1, a mixture of sodium salts of phenylacetylglutamine and phenylacetic acid at a ratio of 1:4, prolongs the recurrence-free interval of HCC patients who undergo frequent treatments for recurrence. Ten patients were enrolled in this trial, 2 in stage I, 6 in stage II, 1 in stage III, 1 in stage IV-B at initial diagnosis. Ten patients experienced 35 recurrence-free intervals. Recurrence-free intervals during antineoplaston AS2-1 administration were significantly longer than those without antineoplaston AS2-1 (16.19±15.916 versus 5.05±2.897 months: p<0.01). Patients who experienced recurrence-free intervals with and without antineoplaston AS2-1 showed longer intervals during antineoplaston AS2-1 administration than those before and after antineoplaston AS2-1 administration (14.47±13.821 versus 5.07±2.989 versus 5.02±3.009 months: p<0.05). Two patients in stage I showed longer recurrence-free intervals than those in more advanced stages. In conclusion, antineoplaston AS2-1 could not prevent recurrence of HCC but prolonged the recurrence-free interval between regional treatments and improved survival rate of these patients.

Related Articles

Journal Cover

March 2003
Volume 10 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., & Hara, H. (2003). The preventive effect of antineoplaston AS2-1 on HCC recurrence. Oncology Reports, 10, 391-397. https://doi.org/10.3892/or.10.2.391
MLA
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., Hara, H."The preventive effect of antineoplaston AS2-1 on HCC recurrence". Oncology Reports 10.2 (2003): 391-397.
Chicago
Tsuda, H., Sata, M., Kumabe, T., Uchida, M., Hara, H."The preventive effect of antineoplaston AS2-1 on HCC recurrence". Oncology Reports 10, no. 2 (2003): 391-397. https://doi.org/10.3892/or.10.2.391