Differential expression of nuclear lamins in normal and cancerous prostate tissues

  • Authors:
    • Rosella Coradeghini
    • Paola Barboro
    • Alessandra Rubagotti
    • Francesco Boccardo
    • Silvio Parodi
    • Giorgio Carmignani
    • Cristina D'Arrigo
    • Eligio Patrone
    • Cecilia Balbi
  • View Affiliations

  • Published online on: March 1, 2006     https://doi.org/10.3892/or.15.3.609
  • Pages: 609-613
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The process of carcinogenesis is characterized by definite changes in the protein composition of the nuclear matrix. We have recently found that lamins form, in addition to the nuclear lamina, an intranuclear web of thin fibrils. This finding prompted us to address the question of whether changes in the expression of lamins occur in the course of tumor development. In prostate cancer, lamin B undergoes a significant increase; interestingly, its nuclear content strongly correlates with tumor differentiation. Moreover, all the lamins show reproducible alterations in the distribution of the isoelectric variants, suggesting that dephosphorylation events could trigger changes in the pattern of gene expression by inducing structural rearrangements of the nuclear scaffold.

Related Articles

Journal Cover

March 2006
Volume 15 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Coradeghini, R., Barboro, P., Rubagotti, A., Boccardo, F., Parodi, S., Carmignani, G. ... Balbi, C. (2006). Differential expression of nuclear lamins in normal and cancerous prostate tissues. Oncology Reports, 15, 609-613. https://doi.org/10.3892/or.15.3.609
MLA
Coradeghini, R., Barboro, P., Rubagotti, A., Boccardo, F., Parodi, S., Carmignani, G., D'Arrigo, C., Patrone, E., Balbi, C."Differential expression of nuclear lamins in normal and cancerous prostate tissues". Oncology Reports 15.3 (2006): 609-613.
Chicago
Coradeghini, R., Barboro, P., Rubagotti, A., Boccardo, F., Parodi, S., Carmignani, G., D'Arrigo, C., Patrone, E., Balbi, C."Differential expression of nuclear lamins in normal and cancerous prostate tissues". Oncology Reports 15, no. 3 (2006): 609-613. https://doi.org/10.3892/or.15.3.609