microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2

  • Authors:
    • Hao Zhang
    • Xiaobing Cai
    • Yang Wang
    • Hao Tang
    • Daki Tong
    • Fang Ji
  • View Affiliations

  • Published online on: November 1, 2010     https://doi.org/10.3892/or_00000994
  • Pages: 1363-1369
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Abstract

Deregulated microRNAs and their roles in tumorigenesis are still largely unknown. Here, we focused on the roles of miR-143 in osteosarcoma, as previous reports have suggested its importance in some other types of cancer. We found that miR-143 was down-regulated in osteosarcoma cell lines and primary tumor samples, and the restoration of miR-143 reduced cell viability, promoted cell apoptosis and suppressed tumorigenicity. Additionally, Bcl-2, an important antiapoptotic molecule, was identified to be a novel direct target of miR-143, and the proapoptotic function of miR-143 is further suggested to be mainly through the targeting of Bcl-2 expression. Collectively, our data identify the important roles of miR-143 in osteosarcoma pathogenesis and indicate its potential application in cancer therapy.

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November 2010
Volume 24 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang H, Cai X, Wang Y, Tang H, Tong D and Ji F: microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2 . Oncol Rep 24: 1363-1369, 2010
APA
Zhang, H., Cai, X., Wang, Y., Tang, H., Tong, D., & Ji, F. (2010). microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2 . Oncology Reports, 24, 1363-1369. https://doi.org/10.3892/or_00000994
MLA
Zhang, H., Cai, X., Wang, Y., Tang, H., Tong, D., Ji, F."microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2 ". Oncology Reports 24.5 (2010): 1363-1369.
Chicago
Zhang, H., Cai, X., Wang, Y., Tang, H., Tong, D., Ji, F."microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2 ". Oncology Reports 24, no. 5 (2010): 1363-1369. https://doi.org/10.3892/or_00000994