Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws

  • Authors:
    • Marina Gonçalves Diniz
    • Erica Rievrs Borges
    • Flavio Juliano Pimenta
    • Ana Carolina De Mesquita Netto
    • Luiz De Marco
    • Ricardo Santiago Gomez
    • Carolina Cavaliéri Gomes
  • View Affiliations

  • Published online on: December 10, 2010     https://doi.org/10.3892/or.2010.1094
  • Pages: 499-502
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Abstract

WWOX is a tumour suppressor gene altered in various human neoplasms. Deletion of WWOX is associated with bone metabolic defects and development of osteosarcoma in mice. We hypothesized that alterations of this gene are associated with the development of benign and malignant mesenchymal bone related lesions of the jaws. We investigated WWOX mRNA by nested reverse transcription-PCR and direct sequencing and quantitative real-time PCR in two osteosarcoma, two fibrosarcoma, eight ossifying fibroma and two fibrous dysplasia fresh samples. Malignancy was associated with a decreased WWOX mRNA expression. Aberrant transcription pattern was found in five samples; however, the relative quantification (RQ) of the WWOX mRNA in such lesions was not different from those carrying only the wild-type. We provide new evidence of WWOX alterations in osteosarcomas and demonstrate for the first time alterations of this gene in fibrosarcomas as well as in ossifying fibromas of the jaws.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Diniz MG, Borges ER, Pimenta FJ, De Mesquita Netto AC, De Marco L, Gomez RS and Gomes CC: Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws. Oncol Rep 25: 499-502, 2011
APA
Diniz, M.G., Borges, E.R., Pimenta, F.J., De Mesquita Netto, A.C., De Marco, L., Gomez, R.S., & Gomes, C.C. (2011). Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws. Oncology Reports, 25, 499-502. https://doi.org/10.3892/or.2010.1094
MLA
Diniz, M. G., Borges, E. R., Pimenta, F. J., De Mesquita Netto, A. C., De Marco, L., Gomez, R. S., Gomes, C. C."Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws". Oncology Reports 25.2 (2011): 499-502.
Chicago
Diniz, M. G., Borges, E. R., Pimenta, F. J., De Mesquita Netto, A. C., De Marco, L., Gomez, R. S., Gomes, C. C."Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws". Oncology Reports 25, no. 2 (2011): 499-502. https://doi.org/10.3892/or.2010.1094