Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells

  • Authors:
    • Daniela Hofer
    • Gert Schwach
    • Nassim Ghaffari Tabrizi-Wizsy
    • Anton Sadjak
    • Sonja Sturm
    • Hermann Stuppner
    • Roswitha Pfragner
  • View Affiliations

  • Published online on: March 26, 2013     https://doi.org/10.3892/or.2013.2367
  • Pages: 2219-2226
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Abstract

Neuroendocrine tumors respond poorly to radiation and conventional chemotherapy, hence surgical removal of the neoplastic tissue is still the most effective way of treatment. In an attempt to find new therapeutic plant extracts of Christia vespertilionis (CV) their antitumor potential in human medullary thyroid carcinoma (MTC) and human small intestinal neuroendocrine tumor (SI-NET) cell lines were tested. Proliferation and viability were analyzed using cell counting and WST-1 assay. Apoptosis was determined by microscopy, luminescence assays for caspases 3/7, and expression studies of apoptosis-related genes. CV extracts showed antiprolife­rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. Furthermore CV-45 treatment resulted in alterations of gene expression of PDCD5, MTDH and TNFRSF10b in MTC as well as in SI-NET cells. The results indicate that Christia vespertilionis could serve as an anticancer therapeutic for treatment of neuroendocrine tumors.
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June 2013
Volume 29 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hofer D, Schwach G, Ghaffari Tabrizi-Wizsy N, Sadjak A, Sturm S, Stuppner H and Pfragner R: Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells. Oncol Rep 29: 2219-2226, 2013
APA
Hofer, D., Schwach, G., Ghaffari Tabrizi-Wizsy, N., Sadjak, A., Sturm, S., Stuppner, H., & Pfragner, R. (2013). Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells. Oncology Reports, 29, 2219-2226. https://doi.org/10.3892/or.2013.2367
MLA
Hofer, D., Schwach, G., Ghaffari Tabrizi-Wizsy, N., Sadjak, A., Sturm, S., Stuppner, H., Pfragner, R."Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells". Oncology Reports 29.6 (2013): 2219-2226.
Chicago
Hofer, D., Schwach, G., Ghaffari Tabrizi-Wizsy, N., Sadjak, A., Sturm, S., Stuppner, H., Pfragner, R."Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells". Oncology Reports 29, no. 6 (2013): 2219-2226. https://doi.org/10.3892/or.2013.2367