Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines

  • Authors:
    • Xiuping Yan
    • Hu Luo
    • Xiangdong Zhou
    • Bingjing Zhu
    • Yuliang Wang
    • Xiuwu Bian
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  • Published online on: October 3, 2013     https://doi.org/10.3892/or.2013.2784
  • Pages: 2733-2740
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Abstract

Accumulating evidence supports that cancer stem cells (CSCs) are responsible for tumor initiation, progression, distal metastasis and even drug resistance. Although CD90 has been identified as a marker for several types of stem cells, such as liver CSCs, the potential role of CD90 as a marker for lung CSCs has yet to be fully characterized. Our previous study demonstrated that the lung cancer stem-like cells isolated from A549 tumor spheres, which were cultured in serum-free conditioned medium, had stronger proliferation and self-renewal abilities, and expressed higher levels of the stem cell markers Sox2 and Oct4 as compared to A549 adherent cells. In the present study, we identified CD90 as a novel surface marker of CSCs in lung cancer cells. Furthermore, we isolated CD90+ CSCs from lung cancer cell lines A549 and H446. Our results revealed that the CD90+ cells, but not the CD90- cells, from lung cancer cells displayed higher tumorigenic capacity. These findings suggest that CD90 could be a potential marker of lung CSCs and thus provide new insight into further therapeutic strategies of lung cancer.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yan X, Luo H, Zhou X, Zhu B, Wang Y and Bian X: Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines. Oncol Rep 30: 2733-2740, 2013
APA
Yan, X., Luo, H., Zhou, X., Zhu, B., Wang, Y., & Bian, X. (2013). Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines. Oncology Reports, 30, 2733-2740. https://doi.org/10.3892/or.2013.2784
MLA
Yan, X., Luo, H., Zhou, X., Zhu, B., Wang, Y., Bian, X."Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines". Oncology Reports 30.6 (2013): 2733-2740.
Chicago
Yan, X., Luo, H., Zhou, X., Zhu, B., Wang, Y., Bian, X."Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines". Oncology Reports 30, no. 6 (2013): 2733-2740. https://doi.org/10.3892/or.2013.2784