Association of annexin A2 with cancer development (Review)

  • Authors:
    • Xiao-Heng Xu
    • Wei Pan
    • Li-Hua Kang
    • Hui Feng
    • Yan-Qiu Song
  • View Affiliations

  • Published online on: March 5, 2015     https://doi.org/10.3892/or.2015.3837
  • Pages: 2121-2128
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Abstract

Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal expression of ANXA2 are linked to a large number of prevalent diseases, including autoimmune and neurodegenerative disease, antiphospholipid syndrome, inflammation, diabetes mellitus and a series of cancers. Accumulating data suggest that ANXA2 is aberrantly expressed in a wide spectrum of cancers, and exerts profound effects on tumor cell adhesion, proliferation, apoptosis, invasion and metastasis as well as tumor neovascularization via different modes of action. However, despite significant research, our knowledge of the mechanism by which ANXA2 participates in cancer development remains fragmented. The present review systematically summarizes the effects of ANXA2 on tumor progression, in an attempt to gain an improved understanding of the underlying mechanisms and to provide a potential effective target for cancer therapy.
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May-2015
Volume 33 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xu X, Pan W, Kang L, Feng H and Song Y: Association of annexin A2 with cancer development (Review). Oncol Rep 33: 2121-2128, 2015
APA
Xu, X., Pan, W., Kang, L., Feng, H., & Song, Y. (2015). Association of annexin A2 with cancer development (Review). Oncology Reports, 33, 2121-2128. https://doi.org/10.3892/or.2015.3837
MLA
Xu, X., Pan, W., Kang, L., Feng, H., Song, Y."Association of annexin A2 with cancer development (Review)". Oncology Reports 33.5 (2015): 2121-2128.
Chicago
Xu, X., Pan, W., Kang, L., Feng, H., Song, Y."Association of annexin A2 with cancer development (Review)". Oncology Reports 33, no. 5 (2015): 2121-2128. https://doi.org/10.3892/or.2015.3837