miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1

  • Authors:
    • Kangping Lu
    • Jingxuan Wang
    • Ying Song
    • Shu Zhao
    • Hang Liu
    • Dabei Tang
    • Bo Pan
    • Hong Zhao
    • Qingyuan Zhang
  • View Affiliations

  • Published online on: June 4, 2015     https://doi.org/10.3892/or.2015.4025
  • Pages: 995-1002
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Abstract

MicroRNAs (miRNAs) are often aberrantly expressed in breast cancer and are postulated to play a role in its initiation and progression. In the present study, we found that the expression level of miR-24-3p was upregulated in breast cancer in comparison with the level in adjacent normal tissues. Overexpression of miR-24-3p was able to promote cell proliferation and inhibit cell apoptosis in MDA-MB-435 and MDA-MB-468 cells. With the bioinformatic method, we further identified that p27Kip1 is a direct target of miR-24-3p, and its protein level was negatively regulated by miR-24-3p. Therefore, the data reported here demonstrate that miR-24-3p is an important regulator in breast cancer, and imply that the miR-24-3p/p27Kip1 axis has potential as a therapeutic target for breast cancer.
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August-2015
Volume 34 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lu K, Wang J, Song Y, Zhao S, Liu H, Tang D, Pan B, Zhao H and Zhang Q: miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1. Oncol Rep 34: 995-1002, 2015
APA
Lu, K., Wang, J., Song, Y., Zhao, S., Liu, H., Tang, D. ... Zhang, Q. (2015). miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1. Oncology Reports, 34, 995-1002. https://doi.org/10.3892/or.2015.4025
MLA
Lu, K., Wang, J., Song, Y., Zhao, S., Liu, H., Tang, D., Pan, B., Zhao, H., Zhang, Q."miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1". Oncology Reports 34.2 (2015): 995-1002.
Chicago
Lu, K., Wang, J., Song, Y., Zhao, S., Liu, H., Tang, D., Pan, B., Zhao, H., Zhang, Q."miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1". Oncology Reports 34, no. 2 (2015): 995-1002. https://doi.org/10.3892/or.2015.4025