The emerging role of RUNX3 in cancer metastasis (Review)

  • Authors:
    • Feifei Chen
    • Xin Liu
    • Jin Bai
    • Dongsheng Pei
    • Junnian Zheng
  • View Affiliations

  • Published online on: December 24, 2015     https://doi.org/10.3892/or.2015.4515
  • Pages: 1227-1236
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Abstract

Metastasis remains the major driver of mortality in patients with cancer. The multistep metastatic process starts with the dissemination of tumor cells from a primary site and leading to secondary tumor development in an anatomically distant location. Although significant progress has been made in understanding the molecular characteristics of metastasis, many questions remain regarding the intracellular mechanisms governing transition through the various metastatic stages. The runt-related transcription factor 3 (RUNX3) is a downstream effector of the transforming growth factor-β (TGF-β) signaling pathway, and has critical roles in the regulation of cell death by apoptosis, and in angiogenesis, epithelial-to-mesenchymal transition (EMT), cell migration and invasion. RUNX3 functions as a bona fide initiator of carcinogenesis by linking the Wnt oncogenic and TGF-β tumor suppressive pathways. RUNX3 is frequently inactivated in human cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactivation of RUNX3 makes it a putative tumor suppressor in human neoplasia. In the present review, we summarize the proposed roles of RUNX3 in metastasis and, when applicable, highlight the mechanism by which they function.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen F, Liu X, Bai J, Pei D and Zheng J: The emerging role of RUNX3 in cancer metastasis (Review). Oncol Rep 35: 1227-1236, 2016
APA
Chen, F., Liu, X., Bai, J., Pei, D., & Zheng, J. (2016). The emerging role of RUNX3 in cancer metastasis (Review). Oncology Reports, 35, 1227-1236. https://doi.org/10.3892/or.2015.4515
MLA
Chen, F., Liu, X., Bai, J., Pei, D., Zheng, J."The emerging role of RUNX3 in cancer metastasis (Review)". Oncology Reports 35.3 (2016): 1227-1236.
Chicago
Chen, F., Liu, X., Bai, J., Pei, D., Zheng, J."The emerging role of RUNX3 in cancer metastasis (Review)". Oncology Reports 35, no. 3 (2016): 1227-1236. https://doi.org/10.3892/or.2015.4515