miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7

  • Authors:
    • Shao-Mei Zhou
    • Fang Zhang
    • Xue-Bin Chen
    • Cao-Ming Jun
    • Xin Jing
    • Deng-Xiong Wei
    • Yang Xia
    • Yu-Bai Zhou
    • Xiang-Qian Xiao
    • Run-Qing Jia
    • Jing-Tao Li
    • Wang Sheng
    • Yi Zeng
  • View Affiliations

  • Published online on: March 23, 2016     https://doi.org/10.3892/or.2016.4701
  • Pages: 3453-3459
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Abstract

MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level, and play pivotal roles in cancer development and progression. miR-100 has been reported to be significantly downregulated in a variety of cancers, including esophageal cancer. However, the role of miR-100 in human esophageal cancer has not been fully elucidated. We demonstrated that overexpression of miR-100 in esophageal cancer cells markedly inhibited cell proliferation, migration and invasion as well as tumor growth. We subsequently showed that CXCR7 is a direct target gene of miR-100. Our results indicated that miR-100 plays a tumor-suppressor role in esophageal cancer and suggest its potential application for esophageal cancer treatment.
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June-2016
Volume 35 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhou S, Zhang F, Chen X, Jun C, Jing X, Wei D, Xia Y, Zhou Y, Xiao X, Jia R, Jia R, et al: miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7. Oncol Rep 35: 3453-3459, 2016
APA
Zhou, S., Zhang, F., Chen, X., Jun, C., Jing, X., Wei, D. ... Zeng, Y. (2016). miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7. Oncology Reports, 35, 3453-3459. https://doi.org/10.3892/or.2016.4701
MLA
Zhou, S., Zhang, F., Chen, X., Jun, C., Jing, X., Wei, D., Xia, Y., Zhou, Y., Xiao, X., Jia, R., Li, J., Sheng, W., Zeng, Y."miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7". Oncology Reports 35.6 (2016): 3453-3459.
Chicago
Zhou, S., Zhang, F., Chen, X., Jun, C., Jing, X., Wei, D., Xia, Y., Zhou, Y., Xiao, X., Jia, R., Li, J., Sheng, W., Zeng, Y."miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7". Oncology Reports 35, no. 6 (2016): 3453-3459. https://doi.org/10.3892/or.2016.4701