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Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells

  • Authors:
    • Lei Zhu
    • Guangang Tian
    • Qin Yang
    • Gejing De
    • Zhigang Zhang
    • Yahui Wang
    • Huizhen Nie
    • Yanli Zhang
    • Xiaomei Yang
    • Jun Li

  • View Affiliations

  • Published online on: July 11, 2016     https://doi.org/10.3892/or.2016.4931
  • Pages: 1419-1426
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Abstract

Thyroid hormone receptor β1 (TRβ1) is a ligand‑dependent transcription factor that belongs to the superfamily of nuclear receptors. TRβ1 has been found to act as a tumor suppressor in many solid tumors including breast cancer and hepatocellular carcinoma, but its role in the progression of human colorectal cancer (CRC) remains unclear. In this study, microarray data analysis revealed that TRβ1 mRNA was downregulated in CRC tumors compared with that in the normal counterparts in both The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Using a CRC tissue microarray (TMA), we confirmed that the expression of TRβ1 was decreased in human CRC tumor tissues in contrast to normal colorectal mucosal tissues. Notably, the TRβ1 expression was strongly correlated with tumor size (p=0.045). Furthermore, we found that CRC cell proliferation and migration were significantly inhibited by TRβ1 overexpression in vitro. Mechanistic studies indicated that activated phosphorylated Akt was clearly suppressed by TRβ1 in the CRC tissues and cells. In conclusion, this study provides evidence that TRβ1 plays a critical role in the progression of CRC via the PI3K/Akt pathway, and the TRβ1 gene may represent a novel target for CRC therapeutics.
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September-2016
Volume 36 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Source Normalized Impact per Paper (SNIP): 0.786
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Spandidos Publications style
Zhu L, Tian G, Yang Q, De G, Zhang Z, Wang Y, Nie H, Zhang Y, Yang X, Li J, Li J, et al: Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells. Oncol Rep 36: 1419-1426, 2016
APA
Zhu, L., Tian, G., Yang, Q., De, G., Zhang, Z., Wang, Y. ... Li, J. (2016). Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells. Oncology Reports, 36, 1419-1426. https://doi.org/10.3892/or.2016.4931
MLA
Zhu, L., Tian, G., Yang, Q., De, G., Zhang, Z., Wang, Y., Nie, H., Zhang, Y., Yang, X., Li, J."Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells". Oncology Reports 36.3 (2016): 1419-1426.
Chicago
Zhu, L., Tian, G., Yang, Q., De, G., Zhang, Z., Wang, Y., Nie, H., Zhang, Y., Yang, X., Li, J."Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells". Oncology Reports 36, no. 3 (2016): 1419-1426. https://doi.org/10.3892/or.2016.4931