MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3

Retraction in: /10.3892/or.2023.8541

  • Authors:
    • Huan Wang
    • Mei Xiong
    • Yongwu Hu
    • Yusheng Sun
    • Qing Ma
  • View Affiliations

  • Published online on: August 23, 2016     https://doi.org/10.3892/or.2016.5029
  • Pages: 2079-2086
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Abstract

Previous studies reported that the aberrant expression of miR-19b in gastric cancer tissues and circulating miR-19b is a potential biomarker to indicate progression of gastric cancer. However, the prognostic significance of miR-19b, and its role and underlying mechanisms in gastric cancer remain poorly investigated. In the present study, we demonstrated that the expression of miR-19b was aberrantly downregulated in both gastric cancer tissues and cell lines. Clinical association analyses disclosed that the reduced expression of miR-19b was significantly associated with adverse clinicopathological characteristics including poor differentiation, large tumor size and advanced tumor-node-metastasis (TNM) stage. Gastric cancer patients with low expression of miR-19b had prominent shorter overall survival and disease-free survival. Gain-of-function studies indicated that miR-19b overexpression inhibited cell proliferation and cell cycle progression in MGC-803 cells. While miR-19b silencing promoted cell proliferation and cell cycle progression in SGC-7901 cells. Furthermore, in vivo experiments showed that miR-19b overexpression suppressed the tumor growth of MGC-803 cells. Notably, miR-19b inversely regulated B-cell CLL/lymphoma 3 (BCL3) abundance in gastric cancer cells. BCL3 was identified as a direct target of miR-19b using luciferase reporter assays. Moreover, BCL3 knockdown abolished the effects of miR-19b knockdown on gastric cancer cells. In conclusion, our data suggest that miR-19b may potentially serve as a novel prognostic biomarker and therapeutic target for gastric cancer.
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October-2016
Volume 36 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang H, Xiong M, Hu Y, Sun Y and Ma Q: MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541. Oncol Rep 36: 2079-2086, 2016
APA
Wang, H., Xiong, M., Hu, Y., Sun, Y., & Ma, Q. (2016). MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541. Oncology Reports, 36, 2079-2086. https://doi.org/10.3892/or.2016.5029
MLA
Wang, H., Xiong, M., Hu, Y., Sun, Y., Ma, Q."MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541". Oncology Reports 36.4 (2016): 2079-2086.
Chicago
Wang, H., Xiong, M., Hu, Y., Sun, Y., Ma, Q."MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541". Oncology Reports 36, no. 4 (2016): 2079-2086. https://doi.org/10.3892/or.2016.5029