MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells

  • Authors:
    • Liang Chen
    • Fang Zhang
    • Xiu-Gui Sheng
    • Shi-Qian Zhang
    • Yue-Ting Chen
    • Bo-Wen Liu
  • View Affiliations

  • Published online on: August 9, 2016     https://doi.org/10.3892/or.2016.5010
  • Pages: 2135-2141
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Abstract

Ovarian cancer is a leading cause of malignant gynecological tumor-related mortality among women. The treatment of ovarian cancer patients continues to be challenging. MicroRNA‑106a (miR‑106a) is widely expressed in diverse human tumors. In the present study, we investigated the biological and pathological roles of miR-106a in ovarian cancers. We found that miR-106a expression was significantly increased in primary ovarian cancer tissues and ovarian cancer cells compared with the level in normal tissues. Ectopic expression of an miR-106a inhibitor attenuated ovarian cancer cell proliferation and invasion. miR-106a promoted the growth and invasion of SKOV3 cells by targeting phosphatase and tensin homolog (PTEN). Furthermore, the present study revealed that IL-6 inhibited miR-106a expression by activating STAT3. Tocilizumab, a humanized anti-human IL-6R antibody, that competitively inhibits IL-6/IL-6R signaling, did not inhibit the proliferation and invasion of SKOV3 cells. In conclusion, our studies revealed that miR-106a was significantly increased in the ovarian cancer tissues and cell lines. Downregulation of the expression of miR-106a inhibited cell growth and metastasis of ovarian cancer cells. Together, the present study suggests that miR‑106a acts as an oncogene in ovarian cancers.
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October-2016
Volume 36 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Chen L, Zhang F, Sheng X, Zhang S, Chen Y and Liu B: MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells. Oncol Rep 36: 2135-2141, 2016
APA
Chen, L., Zhang, F., Sheng, X., Zhang, S., Chen, Y., & Liu, B. (2016). MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells. Oncology Reports, 36, 2135-2141. https://doi.org/10.3892/or.2016.5010
MLA
Chen, L., Zhang, F., Sheng, X., Zhang, S., Chen, Y., Liu, B."MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells". Oncology Reports 36.4 (2016): 2135-2141.
Chicago
Chen, L., Zhang, F., Sheng, X., Zhang, S., Chen, Y., Liu, B."MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells". Oncology Reports 36, no. 4 (2016): 2135-2141. https://doi.org/10.3892/or.2016.5010