CYP24A1-induced vitamin D insufficiency promotes breast cancer growth

  • Authors:
    • Makoto Osanai
    • Gang-Hong Lee
  • View Affiliations

  • Published online on: September 5, 2016     https://doi.org/10.3892/or.2016.5072
  • Pages: 2755-2762
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Abstract

Vitamin D plays a critical role in tissue homeostasis by regulating the expression of genes affecting cell proliferation, differentiation, and apoptosis. The vitamin D 24-hydroxylase CYP24A1 functions in vitamin D target tissues to degrade the hormonal form of vitamin D. Existing knowledge regarding dysregulated CYP24A1 expression supports its candidacy as a putative oncogene. Here, we found that the suppression of constitutive CYP24A1 expression conferred target cells with increased susceptibility to apoptosis and consequently inhibited anchorage-independent growth in breast carcinoma cells. In addition, suppression of vitamin D metabolism following knockdown of CYP24A1 significantly reduced tumor growth in vivo. These data provide substantial evidence for a pro-survival and stimulatory oncogenic effect of CYP24A1 in breast carcinoma cells.
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November-2016
Volume 36 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Osanai M and Osanai M: CYP24A1-induced vitamin D insufficiency promotes breast cancer growth. Oncol Rep 36: 2755-2762, 2016
APA
Osanai, M., & Osanai, M. (2016). CYP24A1-induced vitamin D insufficiency promotes breast cancer growth. Oncology Reports, 36, 2755-2762. https://doi.org/10.3892/or.2016.5072
MLA
Osanai, M., Lee, G."CYP24A1-induced vitamin D insufficiency promotes breast cancer growth". Oncology Reports 36.5 (2016): 2755-2762.
Chicago
Osanai, M., Lee, G."CYP24A1-induced vitamin D insufficiency promotes breast cancer growth". Oncology Reports 36, no. 5 (2016): 2755-2762. https://doi.org/10.3892/or.2016.5072