New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review)

  • Authors:
    • Antonio Stigliano
    • Lidia Cerquetti
    • Pina Lardo
    • Elisa Petrangeli
    • Vincenzo Toscano
  • View Affiliations

  • Published online on: February 7, 2017     https://doi.org/10.3892/or.2017.5427
  • Pages: 1301-1311
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Abstract

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an incidence ranging from 0.7 to 2.0 cases/million people per year. Hypercortisolism represents the most common clinical presentation in many patients although, less frequently, some ACC secreting androgens and estrogens are even more pathognomonic compared to cortisol secretion. Currently, radical surgery, when feasible, is still the only curative therapy. Mitotane, an adrenolytic drug, is used in the adjuvant setting and in combination with chemotherapy drugs in metastatic disease. The use of radiotherapy remains controversial, being indicated only in selected cases. New targeted therapies, such as insulin growth factor-1 (IGF-1), mammalian-target of rapamycin (m-TOR), vascular endothelial growth factor (VEGF) inhibitors and others, have recently been investigated with disappointing clinical results. The partial effectiveness of current treatments mandates the need for new therapeutic strategies against this tumor.
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March-2017
Volume 37 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stigliano A, Cerquetti L, Lardo P, Petrangeli E and Toscano V: New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review). Oncol Rep 37: 1301-1311, 2017
APA
Stigliano, A., Cerquetti, L., Lardo, P., Petrangeli, E., & Toscano, V. (2017). New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review). Oncology Reports, 37, 1301-1311. https://doi.org/10.3892/or.2017.5427
MLA
Stigliano, A., Cerquetti, L., Lardo, P., Petrangeli, E., Toscano, V."New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review)". Oncology Reports 37.3 (2017): 1301-1311.
Chicago
Stigliano, A., Cerquetti, L., Lardo, P., Petrangeli, E., Toscano, V."New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review)". Oncology Reports 37, no. 3 (2017): 1301-1311. https://doi.org/10.3892/or.2017.5427