Diets link metabolic syndrome and colorectal cancer development (Review)

  • Authors:
    • Jirakrit Saetang
    • Surasak Sangkhathat
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  • Published online on: January 18, 2017     https://doi.org/10.3892/or.2017.5385
  • Pages: 1312-1320
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Abstract

Diets have been believed to be an important factor in the development of metabolic syndrome and colorectal cancer (CRC). In recent years, many studies have shown an intimate relationship between mucosal immunity, metabolism and diets, which has led to a greater understanding of the pathophysiology of metabolic syndrome and CRC development. Although the precise effects of diets on oncogenesis have not been compl­etely elucidated, microbiota changes and inflammation are believed to be important factors that influence the development of CRC. Moreover, increased release of pro-inflammatory cytokines and alteration of adipokine levels have been observed in patients with colorectal adenoma and/or CRC, and these all have been considered as the important mechanisms that link diets to the development of metabolic syndrome and CRC. Importantly, a high-fat, low-fiber diet is associated with dysbiosis, and as the gut signature becomes more important in metabolic syndrome and CRC, an increased understanding of diets on bacterial activity in the pathogenesis of metabolic syndrome and CRC will lead to new preventive and therapeutic strategies.
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March-2017
Volume 37 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Saetang J and Saetang J: Diets link metabolic syndrome and colorectal cancer development (Review). Oncol Rep 37: 1312-1320, 2017
APA
Saetang, J., & Saetang, J. (2017). Diets link metabolic syndrome and colorectal cancer development (Review). Oncology Reports, 37, 1312-1320. https://doi.org/10.3892/or.2017.5385
MLA
Saetang, J., Sangkhathat, S."Diets link metabolic syndrome and colorectal cancer development (Review)". Oncology Reports 37.3 (2017): 1312-1320.
Chicago
Saetang, J., Sangkhathat, S."Diets link metabolic syndrome and colorectal cancer development (Review)". Oncology Reports 37, no. 3 (2017): 1312-1320. https://doi.org/10.3892/or.2017.5385