Open Access

MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression

  • Authors:
    • Jiangman Duan
    • Lishan Chen
    • Minyu Zhou
    • Jingwen Zhang
    • Li Sun
    • Na Huang
    • Jianping Bin
    • Yulin Liao
    • Wangjun Liao
  • View Affiliations

  • Published online on: March 22, 2017     https://doi.org/10.3892/or.2017.5519
  • Pages: 2583-2592
  • Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effect of chemotherapeutic agents is limited as a result of drug resistance, which demands prompt solutions provided by clinical studies. To date, the underlying mechanisms of chemotherapy resistance are relatively unknown. Metastasis-associated in colon cancer 1 (MACC1) is an oncogene associated with the progression and prognosis of gastric cancer (GC). Bioinformatic analysis revealed that MACC1 is positively associated with fatty acid synthase (FASN), a major enzyme of lipogenesis, and drives chemoresistance to oxaliplatin in GC. Similar findings were demonstrated in two GC cell lines (BGC-823 and MKN-28) with MACC1 ectopic expression. We next employed FASN inhibitor C75 or siFASN (small interfering RNA targeted to FASN) to block endogenous fatty acid metabolism and it was revealed that cell proliferation and chemoresistance to oxaliplatin induced by MACC1 upregulation were attenuated by FASN blockade to various extents. Conclusively, these outcomes highlight a novel role of MACC1 in GC cell lipogenesis, and suggest that MACC1 may be an attractive target to decrease oxaliplatin resistance in GC.
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May-2017
Volume 37 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Duan J, Chen L, Zhou M, Zhang J, Sun L, Huang N, Bin J, Liao Y and Liao W: MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression. Oncol Rep 37: 2583-2592, 2017
APA
Duan, J., Chen, L., Zhou, M., Zhang, J., Sun, L., Huang, N. ... Liao, W. (2017). MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression. Oncology Reports, 37, 2583-2592. https://doi.org/10.3892/or.2017.5519
MLA
Duan, J., Chen, L., Zhou, M., Zhang, J., Sun, L., Huang, N., Bin, J., Liao, Y., Liao, W."MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression". Oncology Reports 37.5 (2017): 2583-2592.
Chicago
Duan, J., Chen, L., Zhou, M., Zhang, J., Sun, L., Huang, N., Bin, J., Liao, Y., Liao, W."MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression". Oncology Reports 37, no. 5 (2017): 2583-2592. https://doi.org/10.3892/or.2017.5519