Bladder intracavitary hyperthermic perfusion chemotherapy for the prevention of recurrence of non-muscle invasive bladder cancer after transurethral resection

  • Authors:
    • Mingchen Ba
    • Shuzhong Cui
    • Bin Wang
    • Hui Long
    • Zhaofei Yan
    • Shuai Wang
    • Yinbing Wu
    • Yuanfeng Gong
  • View Affiliations

  • Published online on: April 11, 2017     https://doi.org/10.3892/or.2017.5570
  • Pages: 2761-2770
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Abstract

Preventing the recurrence of non-muscle invasive bladder cancer (NMIBC) post-transurethral resection (TUR) remains challenging. The aim of the present study was to investigate the effectiveness and safety of bladder intracavitary hyperthermic perfusion chemotherapy (BHPC) for prevention of NMIBC recurrence post-TUR. Between December 2006 and December 2014, 53 patients with NMIBC who underwent TUR were randomly assigned to receive BHPC (BHPC group, 28 patients) or intravesical chemotherapy alone (chemotherapy group, 25 patients) at the Intracelom Hyperthermic Perfusion Therapy Center of Guangzhou Medical University Cancer Hospital (Guangzhou, China). BHPC was performed by combining perfusion-based hyperthermia with chemotherapeutic agent mitomycin C (MMC) in the bladder, and the chemotherapy group of patients received bladder MMC perfusion. The concentration of MMC in the perfusion fluid and serum were assessed at different time-points. Tumor recurrence, disease-free survival (DFS), and side-effects were recorded and compared between the 2 groups. Results revealed that BHPC was performed smoothly, at ~44̊C in the bladder cavity. Patients tolerated BHPC, and no side-effects were observed. Both BHPC and intravesical chemotherapy achieved a high MMC concentration in the bladder perfusion liquid, but low MMC concentration in the serum, although serum MMC concentrations in the BHPC group were significantly higher (P<0.05). The tumor recurrence rate was significantly lower (10.7 vs. 28.0%; P=0.02) and the DFS period was significantly longer (37±1.2 vs. 19±0.9 months; P=0.001) in the BHPC group than in the chemotherapy group. Our results demonstrated that BHPC is safe and effective for preventing NMIBC recurrence post-TUR and prolongs DFS.
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May-2017
Volume 37 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ba M, Cui S, Wang B, Long H, Yan Z, Wang S, Wu Y and Gong Y: Bladder intracavitary hyperthermic perfusion chemotherapy for the prevention of recurrence of non-muscle invasive bladder cancer after transurethral resection. Oncol Rep 37: 2761-2770, 2017
APA
Ba, M., Cui, S., Wang, B., Long, H., Yan, Z., Wang, S. ... Gong, Y. (2017). Bladder intracavitary hyperthermic perfusion chemotherapy for the prevention of recurrence of non-muscle invasive bladder cancer after transurethral resection. Oncology Reports, 37, 2761-2770. https://doi.org/10.3892/or.2017.5570
MLA
Ba, M., Cui, S., Wang, B., Long, H., Yan, Z., Wang, S., Wu, Y., Gong, Y."Bladder intracavitary hyperthermic perfusion chemotherapy for the prevention of recurrence of non-muscle invasive bladder cancer after transurethral resection". Oncology Reports 37.5 (2017): 2761-2770.
Chicago
Ba, M., Cui, S., Wang, B., Long, H., Yan, Z., Wang, S., Wu, Y., Gong, Y."Bladder intracavitary hyperthermic perfusion chemotherapy for the prevention of recurrence of non-muscle invasive bladder cancer after transurethral resection". Oncology Reports 37, no. 5 (2017): 2761-2770. https://doi.org/10.3892/or.2017.5570