Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway

  • Authors:
    • Dingqing Feng
    • Tingting Zhao
    • Keqin Yan
    • Haiyan Liang
    • Jing Liang
    • Ying Zhou
    • Weidong Zhao
    • Bin Ling
  • View Affiliations

  • Published online on: July 3, 2017     https://doi.org/10.3892/or.2017.5784
  • Pages: 1091-1098
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

It is generally accepted that ovarian cancer is associated with local elevation of gonadotropins (FSH and LH), with repeated ovulation and accompanying expression of inducible cyclooxygenase 2 (COX2). However, the roles of gonadotropins and the concomitant elevation of COX2 in the development of ovarian cancer have not been fully characterized. Herein, we report that excessive FSH/LH exposure did not induce proliferation in ovarian cancer cell lines but significantly promoted cell migration and invasion. Moreover, FSH/LH treatment rapidly upregulated COX2 expression within 24 h, whereas COX1 expression remained unchanged. Further results showed that enhancement of epithelial-mesenchymal transition (EMT) and upregulation of matrix metalloproteinase (MMP)2 and MMP9 contributed to the stimulatory effect of gonadotropins on cell migration and invasion; these effects were sufficiently blocked by a selective COX2 inhibitor. In conclusion, the present study suggests that gonadotropin-induced migration and invasion in ovarian cancer may be caused by EMT and MMP upregulation via a COX2-dependent pathway.
View Figures
View References

Related Articles

Journal Cover

August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Feng D, Zhao T, Yan K, Liang H, Liang J, Zhou Y, Zhao W and Ling B: Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncol Rep 38: 1091-1098, 2017
APA
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y. ... Ling, B. (2017). Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncology Reports, 38, 1091-1098. https://doi.org/10.3892/or.2017.5784
MLA
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y., Zhao, W., Ling, B."Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway". Oncology Reports 38.2 (2017): 1091-1098.
Chicago
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y., Zhao, W., Ling, B."Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway". Oncology Reports 38, no. 2 (2017): 1091-1098. https://doi.org/10.3892/or.2017.5784