Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70

  • Authors:
    • Toru Yanoma
    • Kyoichi Ogata
    • Takehiko Yokobori
    • Munenori Ide
    • Erito Mochiki
    • Yoshitaka Toyomasu
    • Mitsuhiro Yanai
    • Norimichi Kogure
    • Akiharu Kimura
    • Masaki Suzuki
    • Nobuhiro Nakazawa
    • Tuya Bai
    • Tetsunari Oyama
    • Takayuki Asao
    • Ken Shirabe
    • Hiroyuki Kuwano
  • View Affiliations

  • Published online on: July 21, 2017     https://doi.org/10.3892/or.2017.5844
  • Pages: 1500-1506
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Abstract

Heat shock proteins (HSPs), particularly HSP70, help restore normal cellular function following damage caused by stressors. HSP expression in tumor tissues indicates cancer progression, and while the development of HSP inhibitors is progressing, these substances are not widely used to treat cancer. HIKESHI (C11orf73) does not control the intracellular movement of HSP70 at normal temperatures; however, it does regulate the function and movements of HSP70 during heat shock. In this study, we examined the intracellular movement of HSP70 during heat shock to investigate the significance of HIKESHI expression in gastric cancer (GC) and determine if HIKESHI inhibition has cytotoxic effects. We examined HIKESHI using GC cell lines and immunostaining in 207 GC tissue samples. HIKESHI expression in GC tissues was associated with the progression of lymphatic invasion. Suppressing HIKESHI using siRNA did not affect cell viability at normal temperatures. However, suppressing HIKESHI during heat shock inhibited HSP70 nuclear transport and suppressed cell viability. Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory GC.
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September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Suzuki M, et al: Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70 . Oncol Rep 38: 1500-1506, 2017
APA
Yanoma, T., Ogata, K., Yokobori, T., Ide, M., Mochiki, E., Toyomasu, Y. ... Kuwano, H. (2017). Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70 . Oncology Reports, 38, 1500-1506. https://doi.org/10.3892/or.2017.5844
MLA
Yanoma, T., Ogata, K., Yokobori, T., Ide, M., Mochiki, E., Toyomasu, Y., Yanai, M., Kogure, N., Kimura, A., Suzuki, M., Nakazawa, N., Bai, T., Oyama, T., Asao, T., Shirabe, K., Kuwano, H."Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70 ". Oncology Reports 38.3 (2017): 1500-1506.
Chicago
Yanoma, T., Ogata, K., Yokobori, T., Ide, M., Mochiki, E., Toyomasu, Y., Yanai, M., Kogure, N., Kimura, A., Suzuki, M., Nakazawa, N., Bai, T., Oyama, T., Asao, T., Shirabe, K., Kuwano, H."Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70 ". Oncology Reports 38, no. 3 (2017): 1500-1506. https://doi.org/10.3892/or.2017.5844