Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A

  • Authors:
    • Dejun Wu
    • Bing Zhao
    • Xiaoyu Cao
    • Jinghai Wan
  • View Affiliations

  • Published online on: July 12, 2017     https://doi.org/10.3892/or.2017.5806
  • Pages: 1525-1532
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Abstract

Long non-coding RNAs (lncRNAs) have recently been identified in mammals as new modulators of cancer origin and progression participating in various cellular pro­cesses. Long intergenic non-coding RNA for kinase activation (LINK-A), belonging to one of the intergenic lncRNAs, was reported to regulate signaling pathways correlated with triple-negative breast cancer. However, the expression and the functional role of LINK-A in glioma are still unclear. In the present study, we demonstrated that LINK-A was upregulated in human glioma cells compared with the expression noted in normal astrocytes. Knockdown of LINK-A inhibited cell proliferation, migration and invasion in U87 and U251 glioma cells. In addition, we found that lactate dehydrogenase A (LDH-A) was regulated by LINK-A, and enforced expression of LDH-A promoted glycolysis and proliferation in glioma cells. More importantly, we found that LDH-A was involved in the LINK-A-mediated proliferation and invasion of glioma cells. Collectively, these results provide new evidence of an important role for LINK-A in the development of glioma.
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September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wu D, Zhao B, Cao X and Wan J: Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A. Oncol Rep 38: 1525-1532, 2017
APA
Wu, D., Zhao, B., Cao, X., & Wan, J. (2017). Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A. Oncology Reports, 38, 1525-1532. https://doi.org/10.3892/or.2017.5806
MLA
Wu, D., Zhao, B., Cao, X., Wan, J."Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A". Oncology Reports 38.3 (2017): 1525-1532.
Chicago
Wu, D., Zhao, B., Cao, X., Wan, J."Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A". Oncology Reports 38, no. 3 (2017): 1525-1532. https://doi.org/10.3892/or.2017.5806