High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma

  • Authors:
    • Si-Xiang Zeng
    • Qing-Chun Cai
    • Chi-Hua Guo
    • Li-Qiang Zhi
    • Xing Dai
    • Dang-Feng Zhang
    • Wei Ma
  • View Affiliations

  • Published online on: July 21, 2017     https://doi.org/10.3892/or.2017.5842
  • Pages: 1645-1654
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Abstract

The association of TRIM29 overexpression with cancer progression and poor clinical prognosis has been reported in the context of several types of cancers. In the present study, we investigated the prognostic relevance of TRIM29 and its involvement in the progression of human osteosarcoma. To the best of our knowledge, this is the first study to demonstrate a major role of TRIM29 in osteosarcoma. Our results showed that the expression of TRIM29 in osteosarcoma tissues was much higher than that in normal bone tissues. Furthermore, TRIM29 expression was significantly correlated with tumor size, recurrence, metastasis and overall survival time. High expression of TRIM29 and presence of metastasis were independent predictors of poor prognosis in these patients. Both protein and mRNA expression of TRIM29 in osteosarcoma cell lines were significantly higher than those in osteoblast cell line, hFOB1.19. Moreover, the results indicated that TRIM29 promoted migration and invasive growth of osteosarcoma cells by inducing epithelial-mesenchymal transition. Therefore, ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma. In summary, TRIM29 is a potential prognostic biomarker and a therapeutic target for patients with osteosarcoma.
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September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zeng S, Cai Q, Guo C, Zhi L, Dai X, Zhang D and Ma W: High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma. Oncol Rep 38: 1645-1654, 2017
APA
Zeng, S., Cai, Q., Guo, C., Zhi, L., Dai, X., Zhang, D., & Ma, W. (2017). High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma. Oncology Reports, 38, 1645-1654. https://doi.org/10.3892/or.2017.5842
MLA
Zeng, S., Cai, Q., Guo, C., Zhi, L., Dai, X., Zhang, D., Ma, W."High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma". Oncology Reports 38.3 (2017): 1645-1654.
Chicago
Zeng, S., Cai, Q., Guo, C., Zhi, L., Dai, X., Zhang, D., Ma, W."High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma". Oncology Reports 38, no. 3 (2017): 1645-1654. https://doi.org/10.3892/or.2017.5842