Open Access

miR-187 inhibits the growth of cervical cancer cells by targeting FGF9

Retraction in: /10.3892/or.2023.8632

  • Authors:
    • Hua Liang
    • Ruoyu Luo
    • Xiaoqi Chen
    • Yuzi Zhao
    • Aili Tan
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  • Published online on: August 23, 2017     https://doi.org/10.3892/or.2017.5916
  • Pages: 1977-1984
  • Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs) are a cluster of short non-coding RNAs playing critical roles in human cancers. miR-187 was recently found to be a novel cancer-related microRNA. However, the expression and function of miR-187 in cervical cancer have not been investigated. In this study, we found that miR-187 level was decreased in cervical cancer tissues and cell lines. Patients with low level of miR-187 had significantly decreased rate of overall survival (OS) and progression-free survival (DFS). miR-187 overexpression inhibited proliferation and promoted apoptosis of cervical cancer cells, whereas miR-187 knockdown promoted proliferation and inhibited apoptosis of cervical cancer cells. Forced expression of miR-187 inhibited the subcutaneous growth of cervical cancer cells in nude mice. Furthermore, FGF9 was found to be the downstream target of miR-187 in cervical cancer cells. Importantly, targeting FGF9 was required for miR-187 exerting its tumor suppressive roles in cervical cancer cells.
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October-2017
Volume 38 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liang H, Luo R, Chen X, Zhao Y and Tan A: miR-187 inhibits the growth of cervical cancer cells by targeting FGF9 Retraction in /10.3892/or.2023.8632. Oncol Rep 38: 1977-1984, 2017
APA
Liang, H., Luo, R., Chen, X., Zhao, Y., & Tan, A. (2017). miR-187 inhibits the growth of cervical cancer cells by targeting FGF9 Retraction in /10.3892/or.2023.8632. Oncology Reports, 38, 1977-1984. https://doi.org/10.3892/or.2017.5916
MLA
Liang, H., Luo, R., Chen, X., Zhao, Y., Tan, A."miR-187 inhibits the growth of cervical cancer cells by targeting FGF9 Retraction in /10.3892/or.2023.8632". Oncology Reports 38.4 (2017): 1977-1984.
Chicago
Liang, H., Luo, R., Chen, X., Zhao, Y., Tan, A."miR-187 inhibits the growth of cervical cancer cells by targeting FGF9 Retraction in /10.3892/or.2023.8632". Oncology Reports 38, no. 4 (2017): 1977-1984. https://doi.org/10.3892/or.2017.5916