Open Access

Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen‑activated protein kinase pathway

  • Authors:
    • Yuan Zhang
    • Xu Deng
    • Tao Lei
    • Chang Yu
    • Yang Wang
    • Guosheng Zhao
    • Xiaoji Luo
    • Ke Tang
    • Zhengxue Quan
    • Dianming Jiang
  • View Affiliations

  • Published online on: September 18, 2017     https://doi.org/10.3892/or.2017.5960
  • Pages: 2685-2696
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Capsaicin, a pungent molecular compound present in many hot peppers, exerts anticancer activities against various human cancer cell lines by inducing apoptosis. However, the effects of capsaicin on human osteosarcoma (OS) as well as the related mechanisms remain to be fully elucidated. In the present study, the anticancer effects of capsaicin on 3 human OS cell lines (MG63, 143B and HOS) were investigated. Various concentrations of capsaicin (50-300 µM) effectively decreased cell viability in all 3 OS cell lines in a dose-dependent manner. Notably, capsaicin-induced apoptosis was observed when OS cells were treated with relatively high concentrations of capsaicin (starting at 250 µM). In addition, the mitochondrial apoptotic pathway was involved in the capsaicin-induced apoptosis in the OS cells. Meanwhile, our results also indicated that at relatively low concentrations (e.g., 100 µM), capsaicin could inhibit the proliferation, decrease the colony forming ability and induce G0/G1 phase cell cycle arrest of OS cells in a dose-dependent manner. Moreover, our results revealed that the anticancer effects induced by capsaicin on OS cell lines involved multiple MAPK signaling pathways as indicated by inactivation of the ERK1/2 and p38 pathways and activation of the JNK pathway. Furthermore, the results of animal experiments showed that capsaicin inhibited tumor growth in a xenograft model of human OS. In conclusion, these results indicate that capsaicin may exert therapeutic benefits as an adjunct to current cancer therapies but not as an independent anticancer agent.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang Y, Deng X, Lei T, Yu C, Wang Y, Zhao G, Luo X, Tang K, Quan Z, Jiang D, Jiang D, et al: Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen‑activated protein kinase pathway. Oncol Rep 38: 2685-2696, 2017
APA
Zhang, Y., Deng, X., Lei, T., Yu, C., Wang, Y., Zhao, G. ... Jiang, D. (2017). Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen‑activated protein kinase pathway. Oncology Reports, 38, 2685-2696. https://doi.org/10.3892/or.2017.5960
MLA
Zhang, Y., Deng, X., Lei, T., Yu, C., Wang, Y., Zhao, G., Luo, X., Tang, K., Quan, Z., Jiang, D."Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen‑activated protein kinase pathway". Oncology Reports 38.5 (2017): 2685-2696.
Chicago
Zhang, Y., Deng, X., Lei, T., Yu, C., Wang, Y., Zhao, G., Luo, X., Tang, K., Quan, Z., Jiang, D."Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen‑activated protein kinase pathway". Oncology Reports 38, no. 5 (2017): 2685-2696. https://doi.org/10.3892/or.2017.5960