Open Access

TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells

  • Authors:
    • Xue Yang
    • Ji-An Yang
    • Bao-Hui Liu
    • Jian-Ming Liao
    • Fan‑En Yuan
    • Yin-Qiu Tan
    • Qian-Xue Chen
  • View Affiliations

  • Published online on: September 22, 2017     https://doi.org/10.3892/or.2017.5991
  • Pages: 2836-2842
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma is the most common type of primary brain tumor in adults, with high mortality and morbidity rates. More effective therapeutic strategies are imperative. Previous studies have shown that the known p110-β-selective inhibitor TGX-221 blocks the activation of PKB/Akt in PTEN-deficient cells. We treated U87 and U251 glioblastoma cells with TGX-221 to determine the effect of TGX-221. We performed a Cell Counting Kit-8 (CCK-8) test, EDU staining and cell cycle distribution analysis and found that TGX-221 inhibited glioblastoma cell proliferation. Next, the effect of TGX-221 on cell apoptosis was investigated using flow cytometry. These results demonstrated that TGX-221 induced apoptosis in glioblastoma cells. Moreover, migration and invasion assays revealed that TGX-221 inhibited human glioblastoma cell migration and invasion. Collectively, our study revealed that TGX-221 could inhibit proliferation and induce apoptosis in glioblastoma cells.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yang X, Yang J, Liu B, Liao J, Yuan FE, Tan Y and Chen Q: TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells. Oncol Rep 38: 2836-2842, 2017
APA
Yang, X., Yang, J., Liu, B., Liao, J., Yuan, F., Tan, Y., & Chen, Q. (2017). TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells. Oncology Reports, 38, 2836-2842. https://doi.org/10.3892/or.2017.5991
MLA
Yang, X., Yang, J., Liu, B., Liao, J., Yuan, F., Tan, Y., Chen, Q."TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells". Oncology Reports 38.5 (2017): 2836-2842.
Chicago
Yang, X., Yang, J., Liu, B., Liao, J., Yuan, F., Tan, Y., Chen, Q."TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells". Oncology Reports 38, no. 5 (2017): 2836-2842. https://doi.org/10.3892/or.2017.5991