Open Access

A seven-gene prognostic signature for rapid determination of head and neck squamous cell carcinoma survival

  • Authors:
    • Sipeng Shen
    • Jianling Bai
    • Yongyue Wei
    • Guanrong Wang
    • Qingya Li
    • Ruyang Zhang
    • Weiwei Duan
    • Sheng Yang
    • Mulong Du
    • Yang Zhao
    • David C. Christiani
    • Feng Chen
  • View Affiliations

  • Published online on: October 24, 2017     https://doi.org/10.3892/or.2017.6057
  • Pages:3403-3411
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and displays divergent clinical outcomes. Prognostic biomarkers might improve risk stratification and survival prediction. We aimed to investigate the prognostic genes associated with overall survival. A two-step gene selection method was used to develop a seven-gene-based prognostic model based on the training set collected from The Cancer Genome Atlas (TCGA). In addition, the prognostic model was validated in an independent testing set from Gene Expression Omnibus (GEO). The score based on the model successfully distinguished HNSCC survival into high-risk and low-risk groups in the training set (HR, 2.79; 95% CI, 1.98-3.92; P=4.05x10-9) and the testing set (HR, 2.05; 95% CI, 1.35-3.11; P=7.98x10-4). In addition, the score could significantly predict 5-year survival by ROC curves (AUCs for training set, 0.73; testing set, 0.66). Combining risk scores with clinical characteristics improved the AUCs beyond using clinical characteristics alone (training set, from 0.57 to 0.75; testing set, from 0.63 to 0.72). A subgroup sensitivity analysis with HPV status and tumor sites revealed that the risk score was significant in all subgroups except oral cavity tumors of the testing set. Furthermore, HPV-positive status improves survival in oropharyngeal HNSCC but not non-oropharyngeal HNSCC. In conclusion, the seven-gene prognostic signature is a reliable and practical prognostic tool for HNSCC. This approach can add prognostic value to clinical characteristics and provides a new possibility for individualized treatment.

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December 2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

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Copy and paste a formatted citation
APA
Shen, S., Bai, J., Wei, Y., Wang, G., Li, Q., Zhang, R. ... Chen, F. (2017). A seven-gene prognostic signature for rapid determination of head and neck squamous cell carcinoma survival. Oncology Reports, 38, 3403-3411. https://doi.org/10.3892/or.2017.6057
MLA
Shen, S., Bai, J., Wei, Y., Wang, G., Li, Q., Zhang, R., Duan, W., Yang, S., Du, M., Zhao, Y., Christiani, D. C., Chen, F."A seven-gene prognostic signature for rapid determination of head and neck squamous cell carcinoma survival". Oncology Reports 38.6 (2017): 3403-3411.
Chicago
Shen, S., Bai, J., Wei, Y., Wang, G., Li, Q., Zhang, R., Duan, W., Yang, S., Du, M., Zhao, Y., Christiani, D. C., Chen, F."A seven-gene prognostic signature for rapid determination of head and neck squamous cell carcinoma survival". Oncology Reports 38, no. 6 (2017): 3403-3411. https://doi.org/10.3892/or.2017.6057