Inhibitory effects of Schisandrin B on human prostate cancer cells

  • Authors:
    • Moussa Ide Nasser
    • Tingyu Han
    • Salah Adlat
    • Yuxin Tian
    • Nan Jiang
  • View Affiliations

  • Published online on: October 15, 2018     https://doi.org/10.3892/or.2018.6791
  • Pages: 677-685
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Abstract

Prostate cancer is a serious affliction worldwide. Although much progress has been made in the study of prostate cancer prevention and treatment, less attention has been paid to the molecular mechanism of the disease. The molecular arrangement by which Schisandrin B (Sch B) induces human prostate cancer cytotoxicity was comprehensively examined in the present study. As indicated by the results of flow cytometric and western blot analysis, Sch B could inhibit prostate cancer cell proliferation and promote DU145 and LNCaP cell apoptosis and S‑phase cell arrest. Moreover, real‑time PCR, flow cytometry and western blot result revealed that the cell apoptosis process induced by Sch B in LNCaP cells was associated with its capacity to generate oxidative stress, its inhibition of androgen receptor and the phosphorylation of PI3K/AKT and STA3/JAK2. The data from the present study demonstrated the antitumor effects and the potential pharmacological application of Sch B as an efficient drug for prostate cancer.
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January-2019
Volume 41 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nasser MI, Han T, Adlat S, Tian Y and Jiang N: Inhibitory effects of Schisandrin B on human prostate cancer cells. Oncol Rep 41: 677-685, 2019
APA
Nasser, M.I., Han, T., Adlat, S., Tian, Y., & Jiang, N. (2019). Inhibitory effects of Schisandrin B on human prostate cancer cells. Oncology Reports, 41, 677-685. https://doi.org/10.3892/or.2018.6791
MLA
Nasser, M. I., Han, T., Adlat, S., Tian, Y., Jiang, N."Inhibitory effects of Schisandrin B on human prostate cancer cells". Oncology Reports 41.1 (2019): 677-685.
Chicago
Nasser, M. I., Han, T., Adlat, S., Tian, Y., Jiang, N."Inhibitory effects of Schisandrin B on human prostate cancer cells". Oncology Reports 41, no. 1 (2019): 677-685. https://doi.org/10.3892/or.2018.6791