Open Access

CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway

  • Authors:
    • Mei Zheng
    • Qin Zhou
    • Xingguang Liu
    • Chengze Wang
    • Gangli Liu
  • View Affiliations

  • Published online on: January 10, 2019     https://doi.org/10.3892/or.2019.6963
  • Pages: 1531-1538
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The tumorigenesis and metastasis of tumors are associated with human collagen triple helix repeats containing 1 (CTHRC1). To study the effects and possible impacting mechanisms of CTHRC1 on human cervical carcinoma development, samples of paraffin‑embedded cervical carcinoma and HeLa cells were examined. Immunofluorescence, cell wound scratch assay, western blot analysis and Transwell invasion assay were used to evaluate HeLa cells in response to silencing of the CTHRC1 gene in cervical carcinoma. The expression levels of gap‑associated proteins of the Wnt/PCP pathway in paraffin‑embedded cervical carcinoma samples were also evaluated by immunohistochemical staining. CTHRC1 promoted the migration and invasion of HeLa cells in vitro, downregulated Ror2 and p‑c‑Jun and activated the Wnt/PCP pathway. Furthermore, the expression of p‑c‑Jun, Ror2 and Wnt5a was increased after overexpression of CTHRC1 as revealed in HeLa cells compared to control group. The present experiments revealed that CTHRC1 promoted HeLa cell progression by activating the Wnt/PCP signaling pathway and may play a key role in the invasion and metastasis of cervical carcinoma.
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March-2019
Volume 41 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zheng M, Zhou Q, Liu X, Wang C and Liu G: CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway. Oncol Rep 41: 1531-1538, 2019
APA
Zheng, M., Zhou, Q., Liu, X., Wang, C., & Liu, G. (2019). CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway. Oncology Reports, 41, 1531-1538. https://doi.org/10.3892/or.2019.6963
MLA
Zheng, M., Zhou, Q., Liu, X., Wang, C., Liu, G."CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway". Oncology Reports 41.3 (2019): 1531-1538.
Chicago
Zheng, M., Zhou, Q., Liu, X., Wang, C., Liu, G."CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway". Oncology Reports 41, no. 3 (2019): 1531-1538. https://doi.org/10.3892/or.2019.6963