Open Access

SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer

  • Authors:
    • Ya‑Dong Dong
    • Yan‑Li Yuan
    • Hai‑Bo Yu
    • Guang‑Jin Tian
    • De‑Yu Li
  • View Affiliations

  • Published online on: December 21, 2018     https://doi.org/10.3892/or.2018.6952
  • Pages: 1649-1657
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in GC tissues. Furthermore, SHCBP1 was revealed to be highly expressed in GC cell lines MGC‑803 and SGC‑7901 cells, and downregulation of SHCBP1 significantly inhibited GC cell proliferation. Furthermore, SHCBP1 expression promoted cell cycle progression and inhibition of apoptosis. Since the CDK4, cyclin D1 and caspase family proteins play important roles in cell cycle and apoptosis regulation, it was examined whether there was an association between SHCBP1 and these signaling pathways in GC. Our results revealed that SHCBP1 promoted cell cycle progression by regulating the CDK4‑cyclin D1 cascade and suppressed caspase‑3, caspase PARP‑dependent apoptotic pathways. Cell invasion and metastasis experiments also revealed that SHCBP1 promoted tumor growth and invasiveness. These tumor‑promoting functions of SHCBP1 may provide a potential molecular basis for the diagnosis and targeted therapy of GC.
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March-2019
Volume 41 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Dong YD, Yuan YL, Yu HB, Tian GJ and Li DY: SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer. Oncol Rep 41: 1649-1657, 2019
APA
Dong, Y., Yuan, Y., Yu, H., Tian, G., & Li, D. (2019). SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer. Oncology Reports, 41, 1649-1657. https://doi.org/10.3892/or.2018.6952
MLA
Dong, Y., Yuan, Y., Yu, H., Tian, G., Li, D."SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer". Oncology Reports 41.3 (2019): 1649-1657.
Chicago
Dong, Y., Yuan, Y., Yu, H., Tian, G., Li, D."SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer". Oncology Reports 41, no. 3 (2019): 1649-1657. https://doi.org/10.3892/or.2018.6952