Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat colon cancer.

  • Authors:
    • P Bobek
    • S Galbavy
    • L Ozdin
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/or.5.3.727
  • Pages:727-757
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Abstract

The effect of 5% of dried oyster mushroom (Pleurotus ostreatus) in the diet on the dimethylhydrazine (DMH)-induced colon carcinogenesis was studied in male Wistar rats. DMH in a dose of 20 mg/kg of body weight was applied to animals once a week during a period of 12 weeks. Mushroom diet was applied either after treatment with DMH for another 21 weeks or during the whole experiment. Mushroom diet reduced significantly the incidence of lymphoid hyperplasia foci when mushroom was supplemented during the whole experiment. Tumour lesions could be characterized either as carcinoma in situ, or as infiltrating adenocarcinoma. Mushroom diet did not affect significantly the incidence of tumours. Nevertheless, a reduction in total number of tumours was observed in both groups of animals fed mushroom diet. A significant reduction of the number of tumour foci of the type carcinoma in situ was observed in animals fed the oyster mushroom during the whole experiment. Also these animals had the significantly lower number of aberrant crypt foci. Mushroom diet reduced the ornithine decarboxylase activity in the colon and in the liver when oyster mushroom diet was administered during the whole experiment.

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May 1998
Volume 5 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
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APA
Bobek, P., Galbavy, S., & Ozdin, L. (1998). Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat colon cancer.. Oncology Reports, 5, 727-757. https://doi.org/10.3892/or.5.3.727
MLA
Bobek, P., Galbavy, S., Ozdin, L."Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat colon cancer.". Oncology Reports 5.3 (1998): 727-757.
Chicago
Bobek, P., Galbavy, S., Ozdin, L."Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat colon cancer.". Oncology Reports 5, no. 3 (1998): 727-757. https://doi.org/10.3892/or.5.3.727