Benefits of using probiotics as adjuvants in anticancer therapy (Review)
- Authors:
- Silvia Vivarelli
- Luca Falzone
- Maria Sofia Basile
- Daria Nicolosi
- Carlo Genovese
- Massimo Libra
- Mario Salmeri
-
Affiliations: Department of Biomedical and Biotechnological Sciences, University of Catania, I-95123 Catania, Italy - Published online on: June 3, 2019 https://doi.org/10.3892/wasj.2019.13
- Pages: 125-135
-
Copyright: © Vivarelli et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Ursell LK, Metcalf JL, Parfrey LW and Knight R: Defining the human microbiome. Nutr Rev. 70 (Suppl 1):S38–S44. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Zhang YJ, Li S, Gan RY, Zhou T, Xu DP and Li HB: Impacts of gut bacteria on human health and diseases. Int J Mol Sci. 16:7493–7519. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Feng Q, Chen WD and Wang YD: Gut Microbiota: An Integral Moderator in Health and Disease. Front Microbiol. 9(151)2018.PubMed/NCBI View Article : Google Scholar | |
|
Lynch SV and Pedersen O: The Human Intestinal Microbiome in Health and Disease. N Engl J Med. 375:2369–2379. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Greenhalgh K, Meyer KM, Aagaard KM and Wilmes P: The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime. Environ Microbiol. 18:2103–2116. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Neuman H, Debelius JW, Knight R and Koren O: Microbial endocrinology: The interplay between the microbiota and the endocrine system. FEMS Microbiol Rev. 39:509–521. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Ceranowicz P, Warzecha Z and Dembinski A: Peptidyl hormones of endocrine cells origin in the gut--their discovery and physiological relevance. J Physiol Pharmacol. 66:11–27. 2015.PubMed/NCBI | |
|
Sandrini S, Aldriwesh M, Alruways M and Freestone P: Microbial endocrinology: Host-bacteria communication within the gut microbiome. J Endocrinol. 225:R21–R34. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Ravussin Y, Koren O, Spor A, LeDuc C, Gutman R, Stombaugh J, Knight R, Ley RE and Leibel RL: Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring). 20:738–747. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Queipo-Ortuño MI, Seoane LM, Murri M, Pardo M, Gomez-Zumaquero JM, Cardona F, Casanueva F and Tinahones FJ: Gut microbiota composition in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels. PLoS One. 8(e65465)2013.PubMed/NCBI View Article : Google Scholar | |
|
Gensollen T, Iyer SS, Kasper DL and Blumberg RS: How colonization by microbiota in early life shapes the immune system. Science. 352:539–544. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Schmidt TSB, Raes J and Bork P: The Human Gut Microbiome: From Association to Modulation. Cell. 172:1198–1215. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Bultman SJ: Emerging roles of the microbiome in cancer. Carcinogenesis. 35:249–255. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Cani PD: Human gut microbiome: Hopes, threats and promises. Gut. 67:1716–1725. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Mohajeri MH, Brummer RJM, Rastall RA, Weersma RK, Harmsen HJM, Faas M and Eggersdorfer M: The role of the microbiome for human health: From basic science to clinical applications. Eur J Nutr. 57 (Suppl 1):1–14. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Fukui H, Xu X and Miwa H: Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders. J Neurogastroenterol Motil. 24:367–386. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF and Dinan TG: Minireview: Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 28:1221–1238. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Vaishnava S, Behrendt CL, Ismail AS, Eckmann L and Hooper LV: Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA. 105:20858–20863. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Belkaid Y and Naik S: Compartmentalized and systemic control of tissue immunity by commensals. Nat Immunol. 14:646–653. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Magnúsdóttir S, Ravcheev D, de Crécy-Lagard V and Thiele I: Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes. Front Genet. 6(148)2015.PubMed/NCBI View Article : Google Scholar | |
|
Carding S, Verbeke K, Vipond DT, Corfe BM and Owen LJ: Dysbiosis of the gut microbiota in disease. Microb Ecol Health Dis. 26(26191)2015.PubMed/NCBI View Article : Google Scholar | |
|
Grice EA and Segre JA: The human microbiome: Our second genome. Annu Rev Genomics Hum Genet. 13:151–170. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, et al: Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell. 168:928–943.e11. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, et al: A single-cell survey of the small intestinal epithelium. Nature. 551:333–339. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Nash AK, Auchtung TA, Wong MC, Smith DP, Gesell JR, Ross MC, Stewart CJ, Metcalf GA, Muzny DM, Gibbs RA, et al: The gut mycobiome of the Human Microbiome Project healthy cohort. Microbiome. 5(153)2017.PubMed/NCBI View Article : Google Scholar | |
|
Lloyd-Price J, Mahurkar A, Rahnavard G, Crabtree J, Orvis J, Hall AB, Brady A, Creasy HH, McCracken C, Giglio MG, et al: Strains, functions and dynamics in the expanded Human Microbiome Project. Nature. 550:61–66. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, Costea PI, Godneva A, Kalka IN, Bar N, et al: Environment dominates over host genetics in shaping human gut microbiota. Nature. 555:210–215. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Korem T, Zeevi D, Suez J, Weinberger A, Avnit-Sagi T, Pompan-Lotan M, Matot E, Jona G, Harmelin A, Cohen N, et al: Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science. 349:1101–1106. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Lloyd-Price J, Abu-Ali G and Huttenhower C: The healthy human microbiome. Genome Med. 8(51)2016.PubMed/NCBI View Article : Google Scholar | |
|
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al: Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 11:506–514. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Pandey KR, Naik SR and Vakil BV: Probiotics, prebiotics and synbiotics- a review. J Food Sci Technol. 52:7577–7587. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Tsai YL, Lin TL, Chang CJ, Wu TR, Lai WF, Lu CC and Lai HC: Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 26(3)2019.PubMed/NCBI View Article : Google Scholar | |
|
Goodman B and Gardner H: The microbiome and cancer. J Pathol. 244:667–676. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Tomasetti C and Vogelstein B: Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 347:78–81. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Ashford NA, Bauman P, Brown HS, Clapp RW, Finkel AM, Gee D, Hattis DB, Martuzzi M, Sasco AJ and Sass JB: Cancer risk: Role of environment. Science. 347(727)2015.PubMed/NCBI View Article : Google Scholar | |
|
Polo A, Crispo A, Cerino P, Falzone L, Candido S, Giudice A, De Petro G, Ciliberto G, Montella M, Budillon A, et al: Environment and bladder cancer: Molecular analysis by interaction networks. Oncotarget. 8:65240–65252. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Marconi A, Loreto C, Franco S, Spandidos DA and Libra M: Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review). Mol Med Rep. 14:4467–4474. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B and Aggarwal BB: Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 25:2097–2116. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, et al: Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 3:524–548. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, Casey DC, Charlson FJ, Chen AZ, Coates MM, et al: GBD 2015 Mortality and Causes of Death Collaborators: Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 388:1459–1544. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Rapisarda V, Salemi R, Marconi A, Loreto C, Graziano AC, Cardile V, Basile MS, Candido S, Falzone L, Spandidos DA, et al: Fluoro-edenite induces fibulin-3 overexpression in non-malignant human mesothelial cells. Oncol Lett. 12:3363–3367. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Rapisarda V, Ledda C, Matera S, Fago L, Arrabito G, Falzone L, Marconi A, Libra M and Loreto C: Absence of t(14;18) chromosome translocation in agricultural workers after short-term exposure to pesticides. Mol Med Rep. 15:3379–3382. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Fenga C, Gangemi S, Di Salvatore V, Falzone L and Libra M: Immunological effects of occupational exposure to lead (Review). Mol Med Rep. 15:3355–3360. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Guarneri C, Bevelacqua V, Polesel J, Falzone L, Cannavò PS, Spandidos DA, Malaponte G and Libra M: NF-κB inhibition is associated with OPN/MMP-9 downregulation in cutaneous melanoma. Oncol Rep. 37:737–746. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Salemi R, Falzone L, Madonna G, Polesel J, Cinà D, Mallardo D, Ascierto PA, Libra M and Candido S: MMP-9 as a Candidate Marker of Response to BRAF Inhibitors in Melanoma Patients With BRAFV600E Mutation Detected in Circulating-Free DNA. Front Pharmacol. 9(856)2018.PubMed/NCBI View Article : Google Scholar | |
|
Leonardi GC, Falzone L, Salemi R, Zanghì A, Spandidos DA, Mccubrey JA, Candido S and Libra M: Cutaneous melanoma: From pathogenesis to therapy (Review). Int J Oncol. 52:1071–1080. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Bhang HE, Ruddy DA, Krishnamurthy Radhakrishna V, Caushi JX, Zhao R, Hims MM, Singh AP, Kao I, Rakiec D, Shaw P, et al: Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nat Med. 21:440–448. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Kloor M and von Knebel Doeberitz M: The Immune Biology of Microsatellite-Unstable Cancer. Trends Cancer. 2:121–133. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Carter SL, Eklund AC, Kohane IS, Harris LN and Szallasi Z: A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet. 38:1043–1048. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Dagogo-Jack I and Shaw AT: Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol. 15:81–94. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Romano GL, Salemi R, Bucolo C, Tomasello B, Lupo G, Anfuso CD, Spandidos DA, Libra M and Candido S: Prognostic significance of deregulated microRNAs in uveal melanomas. Mol Med Rep. 19:2599–2610. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Battaglia R, Palini S, Vento ME, La Ferlita A, Lo Faro MJ, Caroppo E, Borzì P, Falzone L, Barbagallo D, Ragusa M, et al: Identification of extracellular vesicles and characterization of miRNA expression profiles in human blastocoel fluid. Sci Rep. 9(84)2019.PubMed/NCBI View Article : Google Scholar | |
|
Basile MS, Fagone P, Mangano K, Mammana S, Magro G, Salvatorelli L, Li Destri G, La Greca G, Nicoletti F, Puleo S and Pesce A: KCNMA1 Expression is Downregulated in Colorectal Cancer via Epigenetic Mechanisms. Cancers (Basel). 11pii. (E245)2019.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Scola L, Zanghì A, Biondi A, Di Cataldo A, Libra M and Candido S: Integrated analysis of colorectal cancer microRNA datasets: Identification of microRNAs associated with tumor development. Aging (Albany NY). 10:1000–1014. 2018.PubMed/NCBI View Article : Google Scholar | |
|
McCubrey JA, Fitzgerald TL, Yang LV, Lertpiriyapong K, Steelman LS, Abrams SL, Montalto G, Cervello M, Neri LM, Cocco L, et al: Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells. Oncotarget. 8:14221–14250. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Candido S, Salemi R, Basile MS, Scalisi A, McCubrey JA, Torino F, Signorelli SS, Montella M and Libra M: Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer. Oncotarget. 7:72758–72766. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Hafsi S, Candido S, Maestro R, Falzone L, Soua Z, Bonavida B, Spandidos DA and Libra M: Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study. Oncol Lett. 11:1021–1025. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Lupo G, Rosa GRM, Crimi S, Anfuso CD, Salemi R, Rapisarda E, Libra M and Candido S: Identification of Novel MicroRNAs and Their Diagnostic and Prognostic Significance in Oral Cancer. Cancers (Basel). 11pii. (E610)2019.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Salemi R, Travali S, Scalisi A, McCubrey JA, Candido S and Libra M: MMP-9 overexpression is associated with intragenic hypermethylation of MMP9 gene in melanoma. Aging (Albany NY). 8:933–944. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Dy GK and Adjei AA: Understanding, recognizing, and managing toxicities of targeted anticancer therapies. CA Cancer J Clin. 63:249–279. 2013.PubMed/NCBI View Article : Google Scholar | |
|
McGranahan N and Swanton C: Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell. 27:15–26. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, et al: Cancer Genome Atlas Research Network: The Immune Landscape of Cancer. Immunity. 48:812–830.e14. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Presti M, Mazzon E, Basile MS, Petralia MC, Bramanti A, Colletti G, Bramanti P, Nicoletti F and Fagone P: Overexpression of macrophage migration inhibitory factor and functionally-related genes, D-DT, CD74, CD44, CXCR2 and CXCR4, in glioblastoma. Oncol Lett. 16:2881–2886. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Mangano K, Mazzon E, Basile MS, Di Marco R, Bramanti P, Mammana S, Petralia MC, Fagone P and Nicoletti F: Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach. Oncotarget. 9:17951–17970. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Basile MS, Mazzon E, Russo A, Mammana S, Longo A, Bonfiglio V, Fallico M, Caltabiano R, Fagone P, Nicoletti F, et al: Differential modulation and prognostic values of immune-escape genes in uveal melanoma. PLoS One. 14(e0210276)2019.PubMed/NCBI View Article : Google Scholar | |
|
Emens LA, Ascierto PA, Darcy PK, Demaria S, Eggermont AMM, Redmond WL, Seliger B and Marincola FM: Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape. Eur J Cancer. 81:116–129. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Toh HC: Cancer immunotherapy-the end of the beginning. Linchuang Zhongliuxue Zazhi. 7(12)2018.PubMed/NCBI View Article : Google Scholar | |
|
Roy S and Trinchieri G: Microbiota: A key orchestrator of cancer therapy. Nat Rev Cancer. 17:271–285. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Nayak RR and Turnbaugh PJ: Mirror, mirror on the wall: Which microbiomes will help heal them all? BMC Med. 14(72)2016.PubMed/NCBI View Article : Google Scholar | |
|
Fessler JL and Gajewski TF: The Microbiota: A New Variable Impacting Cancer Treatment Outcomes. Clin Cancer Res. 23:3229–3231. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Schwabe RF and Jobin C: The microbiome and cancer. Nat Rev Cancer. 13:800–812. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A and Wargo JA: The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. Cancer Cell. 33:570–580. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359:91–97. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, et al: Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 359:97–103. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ and Gajewski TF: The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 359:104–108. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Chen Q, Wang C, Chen G, Hu Q and Gu Z: Delivery Strategies for Immune Checkpoint Blockade. Adv Healthc Mater. 7(e1800424)2018.PubMed/NCBI View Article : Google Scholar | |
|
Buchbinder EI and Desai A: CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Am J Clin Oncol. 39:98–106. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Falzone L, Salomone S and Libra M: Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium. Front Pharmacol. 9(1300)2018.PubMed/NCBI View Article : Google Scholar | |
|
Mego M, Holec V, Drgona L, Hainova K, Ciernikova S and Zajac V: Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy. Complement Ther Med. 21:712–723. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Maria-Aggeliki KS, Nikolaos KL, Kyrias GM and Vassilis KE: The potential clinical impact of probiotic treatment for the prevention and/or anti-inflammatory therapeutic effect against radiation induced intestinal mucositis. A review. Recent Pat Inflamm Allergy Drug Discov. 3:195–200. 2009. View Article : Google Scholar | |
|
Rondanelli M, Faliva MA, Perna S, Giacosa A, Peroni G and Castellazzi AM: Using probiotics in clinical practice: Where are we now? A review of existing meta-analyses. Gut Microbes. 8:521–543. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Zitvogel L, Ma Y, Raoult D, Kroemer G and Gajewski TF: The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies. Science. 359:1366–1370. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Vanderhoof JA and Young R: Probiotics in the United States. Clin Infect Dis. 46 (Suppl 2):S67–S72; discussion S144-S151. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Redman MG, Ward EJ and Phillips RS: The efficacy and safety of probiotics in people with cancer: A systematic review. Ann Oncol. 25:1919–1929. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Peterson DE, Boers-Doets CB, Bensadoun RJ, Herrstedt J and Committee EG: ESMO Guidelines Committee Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Ann Oncol. 26 (Suppl 5):v139–v151. 2015. View Article : Google Scholar | |
|
Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, et al: Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO): MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 120:1453–1461. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Gianotti L, Morelli L, Galbiati F, Rocchetti S, Coppola S, Beneduce A, Gilardini C, Zonenschain D, Nespoli A and Braga M: A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J Gastroenterol. 16:167–175. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Demers M, Dagnault A and Desjardins J: A randomized double-blind controlled trial: Impact of probiotics on diarrhea in patients treated with pelvic radiation. Clin Nutr. 33:761–767. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Mego M, Chovanec J, Vochyanova-Andrezalova I, Konkolovsky P, Mikulova M, Reckova M, Miskovska V, Bystricky B, Beniak J, Medvecova L, et al: Prevention of irinotecan induced diarrhea by probiotics: A randomized double blind, placebo controlled pilot study. Complement Ther Med. 23:356–362. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Theodoropoulos GE, Memos NA, Peitsidou K, Karantanos T, Spyropoulos BG and Zografos G: Synbiotics and gastrointestinal function-related quality of life after elective colorectal cancer resection. Ann Gastroenterol. 29:56–62. 2016.PubMed/NCBI | |
|
Consoli ML, da Silva RS, Nicoli JR, Bruña-Romero O, da Silva RG, de Vasconcelos Generoso S and Correia MI: Randomized Clinical Trial: Impact of Oral Administration of Saccharomyces boulardii on Gene Expression of Intestinal Cytokines in Patients Undergoing Colon Resection. JPEN J Parenter Enteral Nutr. 40:1114–1121. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Flesch AT, Tonial ST, Contu PC and Damin DC: Perioperative synbiotics administration decreases postoperative infections in patients with colorectal cancer: A randomized, double-blind clinical trial. Rev Col Bras Cir. 44:567–573. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Goldin BR, Gualtieri LJ and Moore RP: The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutr Cancer. 25:197–204. 1996.PubMed/NCBI View Article : Google Scholar | |
|
Banna GL, Torino F, Marletta F, Santagati M, Salemi R, Cannarozzo E, Falzone L, Ferraù F and Libra M: Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer. Front Pharmacol. 8(603)2017.PubMed/NCBI View Article : Google Scholar | |
|
Lee CS, Ryan EJ and Doherty GA: Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation. World J Gastroenterol. 20:3751–3761. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Khailova L, Baird CH, Rush AA, Barnes C and Wischmeyer PE: Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. Clin Nutr. 36:1549–1557. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Wang Y, Liu L, Moore DJ, Shen X, Peek RM, Acra SA, Li H, Ren X, Polk DB and Yan F: An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells. Mucosal Immunol. 10:373–384. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Fong FLY, Kirjavainen PV and El-Nezami H: Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors. Sci Rep. 6(22845)2016.PubMed/NCBI View Article : Google Scholar | |
|
Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, Torino F, Banna GL, Tonini G and Libra M: Gut Microbiota and Cancer: From Pathogenesis to Therapy. Cancers (Basel). 11pii. (E38)2019.PubMed/NCBI View Article : Google Scholar | |
|
Riehl TE, Alvarado D, Ee X, Zuckerman A, Foster L, Kapoor V, Thotala D, Ciorba MA and Stenson WF: GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells. Gut. 68:1003–1013. 2018.PubMed/NCBI View Article : Google Scholar |
