Expression of human SOX18 in normal tissues and tumors

  • Authors:
    • Tetsuroh Saitoh
    • Masaru Katoh
  • Corresponding author:
  • View Affiliations

  • Published online on: Sunday, September 1, 2002
  • Pages: 339-344 DOI: 10.3892/ijmm.10.3.339

Abstract

SOX proteins are a family of transcription factors with high-mobility-group DNA-binding domain (HMG box) homologous to SRY, which play key roles in embryogenesis. Xenopus Sox17α, Sox17β, Sox3 and mouse Sox7 are reported to be negative regulators of the WNT-β-catenin-TCF signaling pathway. SOX7, SOX17, and SOX18 constitute a subfamily among the SOX gene family. Here, expression of SOX18 mRNA was investigated using Northern blot analysis, RNA dot blot analysis, and cDNA-PCR. SOX18 mRNA was significantly highly expressed in ventricles and inter-ventricular septum of adult heart among various normal human tissues. SOX18 mRNA was relatively highly expressed in stomach and jejunum in the gastrointestinal tract. SOX18 mRNA was relatively highly expressed in TMK1 and MKN45 among 7 gastric cancer cell lines. SOX18 mRNA was expressed in all out of 7 pancreatic cancer cell lines, and was relatively highly expressed in PANC-1, Hs700T, Hs766T and MIA PaCa-2. Expression level of SOX18 mRNA in MCF-7 cells (breast cancer) was not affected by β-estradiol. SOX18 mRNA was expressed in all out of 5 embryonal tumor cell lines, and was relatively highly expressed in NT2 with the potential to differentiate into neuronal cells. Expression level of SOX18 mRNA in NT2 cells was down-regulated by all-trans retinoic acid. This is the first report on comprehensive expression analyses of SOX18 mRNA in normal human tissues and tumors.
Journal Cover

September 2002
Volume 10 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2014 Impact Factor: 2.088
Ranked #22/123 Medicine Research and Experimental
(total number of cites)

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APA
Saitoh, T., & Saitoh, T. (2002). Expression of human SOX18 in normal tissues and tumors. International Journal of Molecular Medicine, 10, 339-344. http://dx.doi.org/10.3892/ijmm.10.3.339
MLA
Saitoh, T., Katoh, M."Expression of human SOX18 in normal tissues and tumors". International Journal of Molecular Medicine 10.3 (2002): 339-344.
Chicago
Saitoh, T., Katoh, M."Expression of human SOX18 in normal tissues and tumors". International Journal of Molecular Medicine 10, no. 3 (2002): 339-344. http://dx.doi.org/10.3892/ijmm.10.3.339